An interference coordination method includes: receiving, by a base station, an interference indicator that is in at least one subframe and sent by a user equipment, where the interference indicator includes RSSIs that are received by the user equipment in the at least one subframe and of all blocks PRBs, or sorted index values of the RSSIs of all the PRBs; determining, by the base station, a first list of candidate user equipment identities with a highest priority according to the interference indicator and uplink resource allocation information in the at least one subframe of a serving cell; and determining, by the base station, that a communication link of a macro cell corresponding to an identity, in the first list of candidate user equipment identities, of a user equipment with smallest interference is a reusable resource for D2D communication.