Management of and region selection for writes to non-volatile memory of an SSD improves performance, reliability, unit cost, and/or development cost of an SSD. A controller receives and determines characteristics of writes (e.g. by analyzing the write data, the write data source, and/or by receiving a hint) and selects a region based on the determined characteristics and properties of regions of non-volatile memory. For example, a controller receives writes determined to be read-only data and selects regions of non-volatile memory containing cells that are likely to have write failures. By placing read-only data in write failure prone regions, the likelihood of an error is reduced, thus improving reliability. As another example, a controller receives writes hinted to be uncompressible and selects regions of non-volatile memory containing uncompressible data.