One embodiment sets forth a method for transforming 3-D images into 2-D rendered images using render target sample masks. A software application creates multiple render targets associated with a surface. For each render target, the software application also creates an associated render target sample mask configured to select one or more samples included in each pixel. Within the graphics pipeline, a pixel shader processes each pixel individually and outputs multiple render target-specific color values. For each render target, a ROP unit uses the associated render target sample mask to select covered samples included in the pixel. Subsequently, the ROP unit uses the render target-specific color value to update the selected samples in the render target, thereby achieving sample-level color granularity. Advantageously, by increasing the effective resolution using render target sample masks, the quality of the rendered image is improved without incurring the performance degradation associated with processing each sample individually.