Invention Grant
- Patent Title: Pyridazinyl derivatives as SMO inhibitors
- Patent Title (中): 哒嗪衍生物作为SMO抑制剂
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Application No.: US13905686Application Date: 2013-05-30
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Publication No.: US09409871B2Publication Date: 2016-08-09
- Inventor: Feng He , Stefan Peukert , Karen Marie Miller-Moslin , Naeem Yusuff , Zhuoliang Chen , Bharat Lagu
- Applicant: NOVARTIS AG
- Applicant Address: CH Basel
- Assignee: NOVARTIS AG
- Current Assignee: NOVARTIS AG
- Current Assignee Address: CH Basel
- Agent Qian Zhang
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D403/14 ; C07D403/04 ; C07D413/14 ; A61K31/501 ; A61K31/4523 ; A61K31/4427 ; C07D237/20 ; C07D401/12 ; C07D403/12 ; C07D471/04 ; C07D237/26 ; A61P35/00
Abstract:
The present invention relates to compounds of formula I: in which L, W, X, Y, Z, m, p, R1, R2, R3, R4 and R7 are defined in the Summary of the Invention; capable of inhibiting the Hedgehog and Smo signaling pathway. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the diagnosis and treatment of pathologies relating to the Hedgehog and Smo signaling pathway, for example, tumor formation, cancer, neoplasia and non-malignant hyperproliferative disorders.
Public/Granted literature
- US20130261299A1 PYRIDAZINYL DERIVATIVES AS SMO INHIBITORS Public/Granted day:2013-10-03
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