公开(公告)号：US10590079B2

公开(公告)日：2020-03-17

申请号：US16081543

申请日：2017-02-28

Applicant: Novartis AG

Inventor： Lei Du-Cuny ,  Feng He ,  Qitao Xiao ,  Guoliang Xun ,  Qiangang Zheng

IPC: A61K31/404 ,  C07D209/42 ,  C07D209/14 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D405/04 ,  C07D405/06 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/506 ,  A61K45/06

Abstract: A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for the treatment of lysine (K)-specific demethylase 1A (LSD1)-mediated diseases or disorders: wherein R1, R2, R3, R4, R5, and R6 are as defined herein.

公开(公告)号：US09409871B2

公开(公告)日：2016-08-09

申请号：US13905686

申请日：2013-05-30

Applicant: NOVARTIS AG

Inventor： Feng He ,  Stefan Peukert ,  Karen Marie Miller-Moslin ,  Naeem Yusuff ,  Zhuoliang Chen ,  Bharat Lagu

IPC: C07D401/14 ,  C07D403/14 ,  C07D403/04 ,  C07D413/14 ,  A61K31/501 ,  A61K31/4523 ,  A61K31/4427 ,  C07D237/20 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04 ,  C07D237/26 ,  A61P35/00

CPC classification number: C07D237/20 ,  A61K31/4427 ,  A61K31/4523 ,  A61K31/501 ,  C07D237/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/14 ,  C07D471/04

Abstract: The present invention relates to compounds of formula I: in which L, W, X, Y, Z, m, p, R1, R2, R3, R4 and R7 are defined in the Summary of the Invention; capable of inhibiting the Hedgehog and Smo signaling pathway. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the diagnosis and treatment of pathologies relating to the Hedgehog and Smo signaling pathway, for example, tumor formation, cancer, neoplasia and non-malignant hyperproliferative disorders.

Abstract translation: 本发明涉及式I化合物：其中L，W，X，Y，Z，m，p，R 1，R 2，R 3，R 4和R 7在发明概述中定义; 能够抑制Hedgehog和Smo信号通路。 本发明还提供了制备本发明化合物的方法，包含这些化合物的药物制剂以及使用这些化合物和组合物诊断和治疗与Hedgehog和Smo信号传导途径有关的病理学的方法，例如肿瘤形成， 癌症，瘤形成和非恶性过度增生性疾病。