Invention Grant
- Patent Title: Tripeptide boronic acid or boronic ester, preparative method and use thereof
- Patent Title (中): 三肽硼酸或硼酸酯，制备方法及其用途
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Application No.: US13379142Application Date: 2010-05-17
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Publication No.: US09421237B2Publication Date: 2016-08-23
- Inventor: Runtao Li , Jingrong Cui , Yongqiang Zhu , Shuyang Yao , Zemei Ge , Tieming Cheng
- Applicant: Runtao Li , Jingrong Cui , Yongqiang Zhu , Shuyang Yao , Zemei Ge , Tieming Cheng
- Applicant Address: CN Beijing
- Assignee: PEKING UNIVERSITY
- Current Assignee: PEKING UNIVERSITY
- Current Assignee Address: CN Beijing
- Agency: Pergament & Cepeda LLP
- Agent Milagros A. Cepeda; Edward D. Pergament
- Priority: CN200910147292 20090619
- International Application: PCT/CN2010/072848 WO 20100517
- International Announcement: WO2010/145376 WO 20101223
- Main IPC: C07K5/08
- IPC: C07K5/08 ; C07F5/02 ; C07F5/04 ; A61K31/69 ; A61K38/06 ; A61P43/00 ; C07K5/083 ; C07K5/087 ; C07K5/097
Abstract:
The present invention discloses proteasome inhibitors of tripeptide boronic acids or boronic esters represented by Formula (I), preparative method and use thereof. The proteasome inhibitors are therapeutical agents for treating malignant tumor, various nervous system degenerative diseases, muscle cachexia or diabetes, wherein the malignant tumor is leukemia, gastric cancer, hepatocarcinoma or nasopharyngeal carcinoma.
Public/Granted literature
- US20120135921A1 TRIPETIDE BORONIC ACID OR BORONIC ESTER, PREPARATIVE METHOD AND USE THEREOF Public/Granted day:2012-05-31
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