中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

4 records (took 0.01 seconds)

    QUATERNARY AMMONIUM SALT COMPOUNDS OF SPIROCYCLOPIPERAZINES, PREPARATION METHODS AND USES THEREOF
    2.
    发明申请
    QUATERNARY AMMONIUM SALT COMPOUNDS OF SPIROCYCLOPIPERAZINES, PREPARATION METHODS AND USES THEREOF 有权
    螺环磷脂的季铵盐化合物，其制备方法及其用途

    公开(公告)号：US20090325929A1

    公开(公告)日：2009-12-31

    申请号：US12305174

    申请日：2007-06-15

    Applicant: Runtao Li ,  Qi Sun ,  Jia Ye ,  Caiqin Yue ,  Xin Wang ,  Zemei Ge ,  Changling Li ,  Tieming Cheng

    Inventor： Runtao Li ,  Qi Sun ,  Jia Ye ,  Caiqin Yue ,  Xin Wang ,  Zemei Ge ,  Changling Li ,  Tieming Cheng

    IPC: A61K31/55 ,  C07D471/10 ,  A61K31/438 ,  A61K31/5386 ,  C07D498/10 ,  C07D487/10

    CPC classification number: C07D471/10 ,  C07D487/10 ,  C07D498/10 ,  C07D513/10 ,  C07D519/00

    Abstract: Compounds represented by general formula (I), their stereoisomers, tautomers, derivatives, prodrugs or pharmaceutically acceptable salts, and their preparation methods or uses for the manufacture of a medicament of analgesics. In which R1 is selected from H, substituted or unsubstituted phenyl, or substituted or unsubstituted heteroaryl; A is bond, or saturated or unsaturated straight-chain or branched-chain hydrocarbon radical; R2, R3 are each independently hydrogen or methyl, which linked with any position of spirocyclo-structure; n and m are each independently integer between 0-2, do not represent 0 at the same time; B and D are each independently C1-C3 straight-chain or branched-chain alkylene; Y is selected from —CHR4—, O, S, —S(O)—, —SO2—, —NR4— and substituted or unsubstituted phenylene, in which R4 represents H, C1-C6 saturated or unsaturated alkyl, methyl or ethyl substituted by substituted or unsubstituted aryl or heteroaryl; and X− is pharmaceutical acceptable organic or inorganic anion. These compounds can be used as muscarine receptor (M-receptor) and/or nicotine acetylcholine receptor (N-receptor) agonist or antagonist. These compounds have good analgesic effect without side effect such as addiction.

    Abstract translation: 由通式（I）表示的化合物，其立体异构体，互变异构体，衍生物，前药或药学上可接受的盐，及其制备方法或用途，用于制备镇痛药物。 其中R1选自H，取代或未取代的苯基或取代或未取代的杂芳基; A是键或饱和或不饱和的直链或支链烃基; R2，R3各自独立地为氢或甲基，其与螺环结构的任何位置连接; n和m各自独立地为0-2之间的整数，不同时为0; B和D各自独立地为C1-C3直链或支链亚烷基; Y选自-CHR 4 - ，O，S，-S（O） - ， - SO 2 - ， - NR 4 - 和取代或未取代的亚苯基，其中R 4表示H，C 1 -C 6饱和或不饱和烷基，甲基或乙基取代 由取代或未取代的芳基或杂芳基取代; X-是药学上可接受的有机或无机阴离子。 这些化合物可用作毒蕈碱受体（M-受体）和/或尼古丁乙酰胆碱受体（N-受体）激动剂或拮抗剂。 这些化合物具有良好的止痛效果，无副作用，如成瘾。

    Quaternary ammonium salt compounds of spirocyclopiperazines, preparation methods and uses thereof
    4.
    发明授权
    Quaternary ammonium salt compounds of spirocyclopiperazines, preparation methods and uses thereof 有权
    螺环吡嗪的季铵盐化合物，其制备方法和用途

    公开(公告)号：US09133195B2

    公开(公告)日：2015-09-15

    申请号：US12305174

    申请日：2007-06-15

    Applicant: Runtao Li ,  Qi Sun ,  Jia Ye ,  Caiqin Yue ,  Xin Wang ,  Zemei Ge ,  Changling Li ,  Tieming Cheng

    Inventor： Runtao Li ,  Qi Sun ,  Jia Ye ,  Caiqin Yue ,  Xin Wang ,  Zemei Ge ,  Changling Li ,  Tieming Cheng

    IPC: A61K31/55 ,  C07D471/10 ,  A61K31/438 ,  A61K31/5386 ,  C07D498/10 ,  C07D487/10 ,  C07D513/10 ,  C07D519/00

    CPC classification number: C07D471/10 ,  C07D487/10 ,  C07D498/10 ,  C07D513/10 ,  C07D519/00

    Abstract: Compounds represented by general formula (I), their stereoisomers, tautomers, derivatives, prodrugs or pharmaceutically acceptable salts, and their preparation methods or uses for the manufacture of a medicament of analgesics. In which R1 is selected from H, substituted or unsubstituted phenyl, or substituted or unsubstituted heteroaryl; A is bond, or saturated or unsaturated straight-chain or branched-chain hydrocarbon radical; R2, R3 are each independently hydrogen or methyl, which linked with any position of spirocyclo-structure; n and m are each independently integer between 0-2, do not represent 0 at the same time; B and D are each independently C1-C3 straight-chain or branched-chain alkylene; Y is selected from —CHR4—, O, S, —S(O)—, —SO2—, —NR4— and substituted or unsubstituted phenylene, in which R4 represents H, C1-C6 saturated or unsaturated alkyl, methyl or ethyl substituted by substituted or unsubstituted aryl or heteroaryl; and X− is pharmaceutical acceptable organic or inorganic anion. These compounds can be used as muscarine receptor (M-receptor) and/or nicotine acetylcholine receptor (N-receptor) agonist or antagonist. These compounds have good analgesic effect without side effect such as addiction.

    Abstract translation: 由通式（I）表示的化合物，其立体异构体，互变异构体，衍生物，前药或药学上可接受的盐，及其制备方法或用途，用于制备镇痛药物。 其中R1选自H，取代或未取代的苯基或取代或未取代的杂芳基; A是键或饱和或不饱和的直链或支链烃基; R2，R3各自独立地为氢或甲基，其与任何位置的螺环结构连接; n和m各自独立地为0-2之间的整数，不同时为0; B和D各自独立地为C1-C3直链或支链亚烷基; Y选自-CHR 4 - ，O，S，-S（O） - ， - SO 2 - ， - NR 4 - 和取代或未取代的亚苯基，其中R 4表示H，C 1 -C 6饱和或不饱和烷基，甲基或乙基取代 由取代或未取代的芳基或杂芳基取代; X-是药学上可接受的有机或无机阴离子。 这些化合物可用作毒蕈碱受体（M-受体）和/或尼古丁乙酰胆碱受体（N-受体）激动剂或拮抗剂。 这些化合物具有良好的止痛效果，无副作用，如成瘾。

Patent Agency Ranking