发明授权
- 专利标题： Therapeutic modulation of ocular surface lubrication
- 专利标题（中）： 眼表面润滑的治疗调节
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申请号： US14831317申请日： 2015-08-20
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公开(公告)号： US09421241B2公开(公告)日： 2016-08-23
- 发明人: Benjamin Sullivan , Tannin A. Schmidt , David A. Sullivan
- 申请人： The Regents of the University of California , Schepens Eye Research Institute
- 申请人地址： US CA Oakland US MA Boston
- 专利权人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA,SCHEPENS EYE RESEARCH INSTITUTE
- 当前专利权人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA,SCHEPENS EYE RESEARCH INSTITUTE
- 当前专利权人地址： US CA Oakland US MA Boston
- 代理机构： Sutherland Asbill & Brennan LLP
- 主分类号： A61K31/568
- IPC分类号： A61K31/568 ; A61K31/728 ; A61K38/14 ; A61K9/00 ; A61K31/715 ; A61K38/13 ; A61K38/18 ; A61K38/17 ; A61K45/06 ; A61K31/685 ; A61K31/688
摘要：
Provided herein are ophthalmically acceptable pharmaceutical compositions comprising PRG4 or lubricant fragments and a PRG4 inducing compound. The PRG4 inducing compound in the pharmaceutical composition of the present invention upregulates PRG4 expression and localization in the ocular surface for efficient surface boundary lubrication. In some instances, pharmaceutical compositions described herein are utilized for treating ophthalmic conditions, e.g., ocular boundary deficiency and symptoms associated therewith.
公开/授权文献
- US20160015780A1 Therapeutic Modulation of Ocular Surface Lubrication 公开/授权日：2016-01-21
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