Provided is a device and a method for eliminating inter-cell interference in Multiple Input Multiple Output (MIMO) wireless communication system. The method for operating a user equipment for eliminating the inter-cell interference includes determining one or more optimum bands among bands not requested to be restricted from a neighboring cell, determining at least one of band and Precoding Matrix Index (PMI) to be requested to be restricted to the neighboring cell among the determined one or more optimum bands, and feeding back at least one of the band and PMI to be requested to be restricted to the neighboring cell to a serving base station.