A centralized scheduling method and apparatus is provided for minimizing inter-cell interference in the wireless communication system adopting femto-eNB-based service coverage expansion (range expansion). The method includes establishing, by a server, a connection with at least one base station, collecting channel information between the at least one base station connected to the server and terminals, determining interfering base stations causing interference to each terminal based on the channel information, and selecting the terminals to be scheduled in consideration of the interfering base stations.