A system, method, and computer program product are provided for accessing multi-sample surfaces. A multi-sample store instruction that specifies data for a single sample of a multi-sample pixel and a sample mask is received and the data for the single sample is stored to each sample of the multi-sample pixel that is enabled according to the sample mask. A multi-sample load instruction that specifies a multi-sample pixel is received, and, in response to executing the multi-sample load instruction, data for one sample of the multi-sample pixel is received. A determination is made that the data for the one sample of the multi-sample pixel represents multi-sample pixel data for at least one additional sample of the multi-sample pixel.