Invention Grant
- Patent Title: Multilayered magnetic micelle compositions and methods for their use
- Patent Title (中): 多层磁性胶束组合物及其使用方法
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Application No.: US14346330Application Date: 2012-09-28
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Publication No.: US09439978B2Publication Date: 2016-09-13
- Inventor: Subhra Mohapatra , Chunyan Wang
- Applicant: Subhra Mohapatra , Chunyan Wang
- Applicant Address: US FL Tampa US DC Washington
- Assignee: University of South Florida,The United States of America as represented by National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), U.S. Government
- Current Assignee: University of South Florida,The United States of America as represented by National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), U.S. Government
- Current Assignee Address: US FL Tampa US DC Washington
- Agency: Thomas | Horstemeyer, LLP
- International Application: PCT/US2012/057859 WO 20120928
- International Announcement: WO2013/049531 WO 20130404
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K47/48 ; A61K49/18 ; C12N15/88 ; C12N15/85
Abstract:
Provided herein are compositions comprising a micelle having a hydrophobic superparmagnetic iron oxide nanoparticle (SPION) core, a first coating comprising a cationic polymer, and a second coating comprising a polynucleotide. Also provided are methods of using the compositions for transfection and/or transformation of a cell with the polynucleotide. Further provided are methods of detecting transfection of a cell with the polynucleotide.
Public/Granted literature
- US20150064116A1 MULTILAYERED MAGNETIC MICELLE COMPOSITIONS AND METHODS FOR THEIR USE Public/Granted day:2015-03-05
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