发明授权
- 专利标题： Base-detecting pore
- 专利标题（中）： 基底检测孔
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申请号： US13002717申请日： 2009-07-06
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公开(公告)号： US09447152B2公开(公告)日： 2016-09-20
- 发明人: James Anthony Clarke , Lakmal Jayasinghe , Terence Reid , John Hagan Pryce Bayley
- 申请人： James Anthony Clarke , Lakmal Jayasinghe , Terence Reid , John Hagan Pryce Bayley
- 申请人地址： GB Oxford
- 专利权人： Oxford Nanopore Technologies Limited
- 当前专利权人： Oxford Nanopore Technologies Limited
- 当前专利权人地址： GB Oxford
- 代理机构： Wolf, Greenfield & Sacks, P.C.
- 国际申请： PCT/GB2009/001690 WO 20090706
- 国际公布： WO2010/004273 WO 20100114
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C07K14/245
摘要：
The invention relates to a mutant α-hemolysin (α-HL) pore which is useful for detecting one or more nucleotides by stochastic sensing. The pore is particularly useful for sequencing DNA or RNA. A molecular adaptor that allows detection of the nucleotide(s) is covalently attached to the pore. The pore is specifically modified to facilitate positioning of the adaptor and may be modified to facilitate covalent attachment.
公开/授权文献
- US20110177498A1 BASE-DETECTING PORE 公开/授权日：2011-07-21
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