发明授权
- 专利标题: Selection by compartmentalised screening
- 专利标题(中): 通过分区筛选进行选择
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申请号: US11238258申请日: 2005-09-29
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公开(公告)号: US09448172B2公开(公告)日: 2016-09-20
- 发明人: Andrew David Griffiths , Chris Abell , Florian Hollfelder , Enrico Mastrobattista
- 申请人: Andrew David Griffiths , Chris Abell , Florian Hollfelder , Enrico Mastrobattista
- 申请人地址: GB London
- 专利权人: Medical Research Council
- 当前专利权人: Medical Research Council
- 当前专利权人地址: GB London
- 代理机构: Brown Rudnick LLP
- 代理商 Thomas C. Meyers
- 优先权: GB0307403.6 20030331
- 主分类号: C40B40/02
- IPC分类号: C40B40/02 ; A61K9/50 ; A61K9/16 ; G01N21/64 ; G01N33/543 ; C40B50/08
摘要:
The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a.) compartmentalizing the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsules; and b.) identifying the compound which binds to or modulates the activity of the target. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.
公开/授权文献
- US20060153924A1 Selection by compartmentalised screening 公开/授权日:2006-07-13