-
1.发明申请METHOD OF PROVIDING A CHEMICAL OR BIOLOGICAL MATERIAL IN QUANTISED FORM AND SYSTEM THEREFOR 有权在数量形式及其系统中提供化学或生物材料的方法公开(公告)号：US20130139477A1
公开(公告)日：2013-06-06
申请号：US13812891
申请日：2011-08-17
申请人： Chris Abell , Wilhelm T.S. Huck , Frank F. Craig
发明人： Chris Abell , Wilhelm T.S. Huck , Frank F. Craig
IPC分类号： B65B3/04
摘要： This invention relates to methods and systems for providing chemical and/or biological materials. Thus we describe a method of providing a chemical or biological material in a quantised form, the method comprising: preparing an emulsion comprising a plurality of microdroplets each holding a controlled amount of said material; storing said chemical or biological material in said microdroplets in said emulsion; transferring a portion of said emulsion microdroplets to a container for transportation; transporting said container to a user of said material, wherein said user receives said material in a quantised form in said microdroplets of said emulsion; and de-emulsifying said received microdroplets containing said material in quantised form to extract said material for subsequent use.
摘要翻译： 本发明涉及用于提供化学和/或生物材料的方法和系统。 因此，我们描述了以量化形式提供化学或生物材料的方法，所述方法包括：制备包含多个微滴的乳液，每个微滴保持受控量的所述材料; 将所述化学或生物材料储存在所述微滴中的所述乳液中; 将一部分所述乳液微滴转移到用于运输的容器中; 将所述容器运送到所述材料的使用者，其中所述使用者在所述乳液的微滴中以量化形式接收所述材料; 并将含有所述材料的所述接收到的微滴以定量的形式去乳化，以提取所述材料以备后续使用。
-
公开(公告)号：US20120010107A1
公开(公告)日：2012-01-12
申请号：US13208614
申请日：2011-08-12
CPC分类号： G01N21/6428 , B01J2219/00596 , B01J2219/00599 , B01J2219/00702 , C40B50/08 , G01N21/6458 , G01N33/5432
摘要： The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, by compartmentalizing the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsules; and identifying the compound which binds to or modulates the activity of the target. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.
-
3.发明申请公开(公告)号：US20110315838A1
公开(公告)日：2011-12-29
申请号：US13169458
申请日：2011-06-27
申请人： Chris Abell
发明人： Chris Abell
CPC分类号： A47B96/061 , A47B55/00 , A47B83/001 , A47B96/06 , E04B2/74 , E04B2002/7483 , E05C19/182 , F16B12/00 , Y10T29/49947 , Y10T403/70
摘要： Apparatuses and methods for connecting office furniture components are disclosed. One embodiment includes a two-piece bracket that attaches a vertical panel adjacent to and extending upward from the top of a second vertical panel, the bracket forming two channels having openings in opposite directions. Another embodiment includes a two-piece bracket that holds two vertical wall panels together, the bracket including a U-shaped member and an L-shaped member connected to one another to form an S-shaped member. Another embodiment includes a two-piece bracket that receives the edge of a panel in a channel between the two pieces and includes a contact surface between the two pieces that is angled to increase the pressure exerted on the panel. Still another embodiment includes a two-piece bracket that holds a shelf atop a wall panel and includes an L-shaped member and a T-shaped member that connect to form a Π-shaped member.
摘要翻译： 公开了用于连接办公家具部件的装置和方法。 一个实施例包括一个两件式托架，其将垂直板与第二垂直板的顶部相邻并向上延伸，托架形成具有相反方向的开口的两个通道。 另一个实施例包括将两个垂直壁板保持在一起的两件式支架，支架包括U形构件和彼此连接以形成S形构件的L形构件。 另一个实施例包括两件式支架，其接收在两件之间的通道中的面板的边缘，并且包括成角度以增加施加在面板上的压力的两个件之间的接触表面。 另一个实施例包括一个两件式托架，其将搁板放置在墙板的顶部，并且包括L形构件和T形构件，所述T形构件和T形构件连接以形成“P”形构件。
-
4.发明授权公开(公告)号：US07718578B2
公开(公告)日：2010-05-18
申请号：US11238257
申请日：2005-09-29
CPC分类号： B01J19/0046 , B01J19/0093 , B01J2219/00497 , B01J2219/005 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00599 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01J2219/00835 , B01J2219/0086 , B01J2219/00894 , B01J2219/00903 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C07K1/047 , C12N15/1075 , C40B20/04 , C40B30/04 , C40B40/06 , C40B40/10 , C40B50/08 , G01N33/5432
摘要： The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalizing two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets. The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalized into the microcapsules.
摘要翻译： 本发明描述了一种合成化合物的方法，包括以下步骤：（a）将两组或多组初级化合物分隔成微胶囊; 使得一部分微胶囊含有两种或更多种化合物; 和（b）通过来自不同组的主要化合物之间的化学反应在微胶囊中形成次级化合物。 本发明进一步允许鉴定与生物化学体系的靶组分结合或调节靶的活性并且被共同分隔成微胶囊的化合物。
-
公开(公告)号：US09857303B2
公开(公告)日：2018-01-02
申请号：US13208614
申请日：2011-08-12
IPC分类号： C40B40/00 , C40B40/06 , G01N21/64 , G01N33/543 , C40B50/08
CPC分类号： G01N21/6428 , B01J2219/00596 , B01J2219/00599 , B01J2219/00702 , C40B50/08 , G01N21/6458 , G01N33/5432
摘要： The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, by compartmentalizing the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsules; and identifying the compound which binds to or modulates the activity of the target. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.
-
公开(公告)号：US09448172B2
公开(公告)日：2016-09-20
申请号：US11238258
申请日：2005-09-29
CPC分类号： G01N21/6428 , B01J2219/00596 , B01J2219/00599 , B01J2219/00702 , C40B50/08 , G01N21/6458 , G01N33/5432
摘要： The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a.) compartmentalizing the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsules; and b.) identifying the compound which binds to or modulates the activity of the target. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.
摘要翻译： 本发明描述了用于鉴定结合生物化学体系的靶组分或调节靶的活性的化合物的方法，包括以下步骤：a）将化合物与靶分隔成微胶囊，使得只有 所有组成部分以任何一个微胶囊中的多份拷贝表示; 和b。）鉴定结合或调节靶标活性的化合物。 本发明能够筛选可用作药物开发潜力的大分子谱系。
-
公开(公告)号：US09144310B2
公开(公告)日：2015-09-29
申请号：US13169458
申请日：2011-06-27
申请人： Chris Abell
发明人： Chris Abell
CPC分类号： A47B96/061 , A47B55/00 , A47B83/001 , A47B96/06 , E04B2/74 , E04B2002/7483 , E05C19/182 , F16B12/00 , Y10T29/49947 , Y10T403/70
摘要： Apparatuses and methods for connecting office furniture components are disclosed. One embodiment includes a two-piece bracket that attaches a vertical panel adjacent to and extending upward from the top of a second vertical panel, the bracket forming two channels having openings in opposite directions. Another embodiment includes a two-piece bracket that holds two vertical wall panels together, the bracket including a U-shaped member and an L-shaped member connected to one another to form an S-shaped member. Another embodiment includes a two-piece bracket that receives the edge of a panel in a channel between the two pieces and includes a contact surface between the two pieces that is angled to increase the pressure exerted on the panel. Still another embodiment includes a two-piece bracket that holds a shelf atop a wall panel and includes an L-shaped member and a T-shaped member that connect to form a Π-shaped member.
摘要翻译： 公开了用于连接办公家具部件的装置和方法。 一个实施例包括一个两件式托架，其将垂直板与第二垂直板的顶部相邻并向上延伸，托架形成具有相反方向的开口的两个通道。 另一个实施例包括将两个垂直壁板保持在一起的两件式支架，支架包括U形构件和彼此连接以形成S形构件的L形构件。 另一个实施例包括两件式支架，其接收在两件之间的通道中的面板的边缘，并且包括成角度以增加施加在面板上的压力的两个件之间的接触表面。 另一个实施例包括一个两件式托架，其将搁板放置在墙板的顶部，并且包括L形构件和T形构件，所述T形构件和T形构件连接以形成“P”形构件。
-
公开(公告)号：US08828210B2
公开(公告)日：2014-09-09
申请号：US12738268
申请日：2008-10-16
CPC分类号： B01J19/0093 , B01J2219/00576 , B01J2219/00599 , B01J2219/00783 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/0086 , B01J2219/00891 , B01J2219/0097 , B01L3/502761 , B01L3/502784 , B01L2300/0867 , B01L2400/0415 , B01L2400/043 , G01N2035/00158
摘要： This invention relates to microfluidic systems and more particularly to methods and apparatus for accessing the contents of micro droplets (114) in an emulsion stream. A method of accessing the contents of a droplet (114) of an emulsion in a microfluidic system, the method comprising: flowing the emulsion alongside a continuous, non-emulsive stream of second fluid (118) to provide an interface (120) between said emulsion and said stream of second fluid (118); and in embodiments applying one or both of an electric (112a, 112b) and magnetic field across said interface (120) to alter a trajectory of a said droplet (114) of said emulsion to cause said droplet to coalesce with said stream of second fluid (118); and accessing said contents of said droplet (114) in said second stream (118).
摘要翻译： 本发明涉及微流体系统，更具体地涉及用于访问乳液流中微滴（114）的内容物的方法和装置。 一种在微流体系统中接触乳液液滴（114）的内容物的方法，所述方法包括：使乳液与第二流体（118）的连续的非乳化流一起流动，以在所述第二流体（118）之间提供界面（120） 乳液和所述第二流体流（118）; 并且在实施例中应用电（112a，112b）和磁场中的一个或两个穿过所述界面（120）以改变所述乳液的所述液滴（114）的轨迹，以使所述液滴与所述第二流体流 （118）; 以及访问所述第二流（118）中的所述液滴（114）的所述内容物。
-
公开(公告)号：US20120091004A1
公开(公告)日：2012-04-19
申请号：US12738268
申请日：2008-10-16
CPC分类号： B01J19/0093 , B01J2219/00576 , B01J2219/00599 , B01J2219/00783 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/0086 , B01J2219/00891 , B01J2219/0097 , B01L3/502761 , B01L3/502784 , B01L2300/0867 , B01L2400/0415 , B01L2400/043 , G01N2035/00158
摘要： This invention relates to microfluidic systems and more particularly to methods and apparatus for accessing the contents of micro droplets (114) in an emulsion stream. A method of accessing the contents of a droplet (114) of an emulsion in a microfluidic system, the method comprising: flowing the emulsion alongside a continuous, non-emulsive stream of second fluid (118) to provide an interface (120) between said emulsion and said stream of second fluid (118); and in embodiments applying one or both of an electric (112a, 112b) and magnetic field across said interface (120) to alter a trajectory of a said droplet (114) of said emulsion to cause said droplet to coalesce with said stream of second fluid (118); and accessing said contents of said droplet (114) in said second stream (118).
摘要翻译： 本发明涉及微流体系统，更具体地涉及用于访问乳液流中微滴（114）的内容物的方法和装置。 一种在微流体系统中接触乳液液滴（114）的内容物的方法，所述方法包括：使乳液与第二流体（118）的连续的非乳化流一起流动，以在所述第二流体（118）之间提供界面（120） 乳液和所述第二流体流（118）; 并且在实施例中应用电（112a，112b）和磁场中的一个或两个穿过所述界面（120）以改变所述乳液的所述液滴（114）的轨迹，以使所述液滴与所述第二流体流 （118）; 以及访问所述第二流（118）中的所述液滴（114）的所述内容物。
-
10.发明申请METHOD OF SYNTHESIS AND TESTING OF COMINATORIAL LIBRARIES USING MICROCAPSULES 审中-公开使用微波消解的合成图谱的合成和测试方法公开(公告)号：US20100210479A1
公开(公告)日：2010-08-19
申请号：US12770006
申请日：2010-04-29
IPC分类号： C40B50/08
CPC分类号： B01J19/0046 , B01J19/0093 , B01J2219/00497 , B01J2219/005 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00599 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01J2219/00835 , B01J2219/0086 , B01J2219/00894 , B01J2219/00903 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C07K1/047 , C12N15/1075 , C40B20/04 , C40B30/04 , C40B40/06 , C40B40/10 , C40B50/08 , G01N33/5432
摘要： Methods for use in the synthesis and identification of molecules which bind to a target component of a biological system or modulate the activity of a target are described.
摘要翻译： 描述了用于合成和鉴定与生物系统的靶组分结合或调节靶的活性的分子的方法。
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.031 秒)