Systems and methods for preparing a cartridge and a projectile for use in a disrupter to launch the projectile toward an explosive device to disable the explosive device. The cartridge may be selected from a group of cartridges and the projectile may be selected from a group of projectiles in accordance with the type of explosive device, the projectile selected, or other considerations for attempting to disable the explosive device. The cartridge and projectile are manually coupled by an operator of the disrupter for use in the disrupter.