A system for multi-rate digital self-interference cancellation including a signal component generation system coupled to a digital transmit signal of a communication system that generates a set of signal components from the digital transmit signal; a multi-rate adaptive filter that transforms the set of signal components into a digital self-interference cancellation signal, according to a transform configuration, to form an interference-reduced receive signal; and a transform adaptor that dynamically sets the transform configuration in response to changes in the interference-reduced receive signal.