发明授权
- 专利标题: Pyrrolidinyl sulfone RORγ modulators
- 专利标题(中): 吡咯烷基砜RORγ调节剂
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申请号: US14590233申请日: 2015-01-06
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公开(公告)号: US09458171B2公开(公告)日: 2016-10-04
- 发明人: Jingwu Duan , T. G. Murali Dhar , Bin Jiang , Zhonghui Lu , Hai-Yun Xiao
- 申请人: BRISTOL-MYERS SQUIBB COMPANY
- 申请人地址: US NJ Princeton
- 专利权人: Bristol-Myers Squibb Company
- 当前专利权人: Bristol-Myers Squibb Company
- 当前专利权人地址: US NJ Princeton
- 代理商 Elliott Korsen
- 主分类号: C07D417/14
- IPC分类号: C07D417/14 ; C07D471/10 ; C07D493/04 ; C07D207/12 ; C07D207/16 ; C07D401/06 ; C07D401/12 ; C07D403/04 ; C07D403/06 ; C07D405/06 ; C07D417/06 ; C07D487/04 ; C07D403/12 ; C07D401/14 ; C07D413/14 ; C07D405/12 ; C07D407/12 ; C07D407/14 ; C07D409/12 ; C07D413/12 ; C07D417/12 ; C07D487/10
摘要:
Described are RORγ modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.
公开/授权文献
- US20150191483A1 PYRROLIDINYL SULFONE RORGAMMA MODULATORS 公开/授权日:2015-07-09
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