Invention Grant
- Patent Title: Pyrrolidinyl sulfone RORγ modulators
- Patent Title (中): 吡咯烷基砜RORγ调节剂
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Application No.: US14590233Application Date: 2015-01-06
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Publication No.: US09458171B2Publication Date: 2016-10-04
- Inventor: Jingwu Duan , T. G. Murali Dhar , Bin Jiang , Zhonghui Lu , Hai-Yun Xiao
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Elliott Korsen
- Main IPC: C07D417/14
- IPC: C07D417/14 ; C07D471/10 ; C07D493/04 ; C07D207/12 ; C07D207/16 ; C07D401/06 ; C07D401/12 ; C07D403/04 ; C07D403/06 ; C07D405/06 ; C07D417/06 ; C07D487/04 ; C07D403/12 ; C07D401/14 ; C07D413/14 ; C07D405/12 ; C07D407/12 ; C07D407/14 ; C07D409/12 ; C07D413/12 ; C07D417/12 ; C07D487/10

Abstract:
Described are RORγ modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.
Public/Granted literature
- US20150191483A1 PYRROLIDINYL SULFONE RORGAMMA MODULATORS Public/Granted day:2015-07-09
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