Invention Grant
- Patent Title: Inhibitor compounds of phosphodiesterase type 10A
- Patent Title (中): 磷酸二酯酶10A型抑制剂化合物
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Application No.: US14854835Application Date: 2015-09-15
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Publication No.: US09475808B2Publication Date: 2016-10-25
- Inventor: Hervé Geneste , Michael Ochse , Karla Drescher , Berthold Behl , Loic Laplanche , Jürgen Dinges , Clarissa Jakob
- Applicant: AbbVie Deutschland GmbH & Co. KG , AbbVie Inc.
- Applicant Address: DE Wiesbaden US IL North Chicago
- Assignee: AbbVie Deutschland GmbH & Co. KG,AbbVie Inc.
- Current Assignee: AbbVie Deutschland GmbH & Co. KG,AbbVie Inc.
- Current Assignee Address: DE Wiesbaden US IL North Chicago
- Agency: Neal Gerber & Eisenberg LLP
- Main IPC: A61K31/54
- IPC: A61K31/54 ; C07D471/04 ; C07D519/00

Abstract:
The present invention relates to compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof: In formula I the variables Het, A, X, Y, Z, R1, R2, R3, R4, R5 and Q are as defined in the claims.The compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof are inhibitors of phosphodiesterase type 10A. Thus, the invention also relates to the use of the compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders.
Public/Granted literature
- US20160002231A1 NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A Public/Granted day:2016-01-07
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