Embodiments of the invention relate to performing run-time instrumentation. Run-time instrumentation is captured, by a processor, based on an instruction stream of instructions of an application program executing on the processor. The capturing includes storing the run-time instrumentation data in a collection buffer of the processor. A run-time instrumentation sample point trigger is detected by the processor. Contents of the collection buffer are copied into a program buffer as a reporting group based on detecting the run-time instrumentation sample point trigger. The program buffer is located in main storage in an address space that is accessible by the application program.