Embodiments include systems and methods for optimization of micro-benchmark analysis for microprocessor designs. For example, embodiments seek to generate a suite of micro-benchmarks and associated weighting factors, which can be used to effectively define a weighted aggregate workload condition for a fine-grained (e.g., RTL) simulation in a manner that is a sufficient proxy for predicted commercial workload conditions. The suite of micro-benchmarks can be appreciably more efficient to simulate than the commercial workload, so that using the suite of micro-benchmarks as a proxy for the commercial workload can provide many benefits, including more efficient iterative design.