A surgical instrument includes an end effector assembly having first and second jaw members moveable relative to one another between a spaced-apart position and an approximated position for grasping tissue therebetween. In the approximated position, the jaw members cooperate to define a cavity that is configured to house tissue grasped between the jaw members. An injectable material configured for injection into the cavity defined by the jaw members is also provided. The injectable material is configured to substantially surround tissue housed within the cavity. The injectable material is transitionable from a first state, facilitating injection of the injectable material into the cavity, to a second state, wherein the injectable material forms about tissue housed within the cavity to occlude tissue.