Examples of the present application provide an interference cancellation method, system, device and a UE. The interference cancellation method of a communication network including a plurality of User Equipments (UEs) and Base Stations (BSs) includes: acquiring a Signal to Noise Ratio (SNR) and Interference to Noise Ratio (INR) of a downlink signal detected by a first UE and a SNR and INR of a downlink signal detected by a second UE, respectively through a first BS and a second BS; and notifying the first BS and the second BS of a transmission mode of associated UEs, wherein the first UE is located in a cell served by the first BS, and the second UE is located in a cell served by the second BS.