发明授权
US09493499B2 Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography
有权
通过阴离子交换色谱法制备纯化的胞苷磷酸唾液酸 - 唾液酸 - 聚环氧烷（CMP-SA-PEG）作为修饰的核苷酸糖的方法
- 专利标题： Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography
- 专利标题（中）： 通过阴离子交换色谱法制备纯化的胞苷磷酸唾液酸 - 唾液酸 - 聚环氧烷（CMP-SA-PEG）作为修饰的核苷酸糖的方法
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申请号： US12663748申请日： 2008-06-12
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公开(公告)号： US09493499B2公开(公告)日： 2016-11-15
- 发明人: Shawn DeFrees , Caryn Bowe
- 申请人： Shawn DeFrees , Caryn Bowe
- 申请人地址： DK
- 专利权人： Novo Nordisk A/S
- 当前专利权人： Novo Nordisk A/S
- 当前专利权人地址： DK
- 代理机构： Leydig, Voit & Mayer, Ltd.
- 国际申请： PCT/US2008/066749 WO 20080612
- 国际公布： WO2008/154639 WO 20081218
- 主分类号： C07H19/10
- IPC分类号： C07H19/10
摘要：
The current invention provides methods (e.g., large-scale processes) for the production of nucleotide sugars, which are modified with a polymeric modifying group, such as poly(alkylene oxide) moieties (e.g., poly(ethylene glycol) or poly(propylene glycol)) moieties. A typical process of the invention includes anion exchange chromatography followed by an ultrafiltration procedure, such as tangential flow filtration. The process of the invention provides modified nucleotide sugars in unexpectedly high purity and high overall yields.
公开/授权文献
- US20100174059A1 PROCESS FOR THE PRODUCTION OF NUCLEOTIDE SUGARS 公开/授权日：2010-07-08
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