A tissue resection device for resecting tissue from a target site within a patient's body. The device includes an elongate shaft having a proximal end and a distal end. An actuation member extends partially through the shaft, and reciprocates within the shaft between a retracted position and an extended position. Multiple snare wires extend through the actuation member, and emerge outwards from a distal portion of the actuation member. The snare wires cooperate and join to form a snare loop, which engages the tissue intended to be resected. The snare loop is configured to enhance friction while engaging the tissue, to resect the tissue.