发明授权
- 专利标题： Cell free DNA diagnostic testing standards
- 专利标题（中）： 无细胞DNA诊断检测标准
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申请号： US14498629申请日： 2014-09-26
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公开(公告)号： US09499870B2公开(公告)日： 2016-11-22
- 发明人: Joshua Babiarz , Bernhard Zimmermann
- 申请人： Natera, Inc.
- 申请人地址： US CA San Carlos
- 专利权人： Natera, Inc.
- 当前专利权人： Natera, Inc.
- 当前专利权人地址： US CA San Carlos
- 代理商 Anton Bokal
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12N15/10
摘要：
Embodiments of the invention include methods and compositions for producing proficiency testing standards for noninvasive prenatal genetic diagnostics and for the detection and monitoring of cancer. The compositions can include a plurality of different nucleosomal DNA fragments derived from either primary cells or cell lines. The amount of the different nucleosomal DNA fragments can be varied so as to simulate naturally occurring cell free DNA samples obtained from the blood of the pregnant woman or naturally occurring cell free DNA samples obtained from the blood of cancer patients.
公开/授权文献
- US20150147815A1 CELL FREE DNA DIAGNOSTIC TESTING STANDARDS 公开/授权日：2015-05-28
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