Provided are a method and apparatus for acquiring channel responses of a self-interference channel and a full-duplex communication device. The method comprises: obtaining an estimate value of a channel response of the self-interfering channel by employing multiple reference signals to perform a channel estimation on the self-interfering channel; determining a stable range of each channel frequency-domain response on the basis of the channel response estimated value; randomly selecting a frequency point within the stable range of each channel frequency-domain response or selecting a frequency point of a greater channel response to serve as an emission frequency point of the reference signals, and, when an interrelation of the channel responses on the emission frequency point and on a non-emission frequency point is acquired, acquiring all the channel responses on time-domain and frequency-domain on the basis of a reception signal corresponding to the reference signals on the emission frequency point.