发明授权
US09512167B2 Optimized synthesis of pure, non-polymorphic, crystalline bile acids with defined particle size
有权
优化了具有规定粒径的纯非多晶型结晶胆汁酸的合成
- 专利标题: Optimized synthesis of pure, non-polymorphic, crystalline bile acids with defined particle size
- 专利标题(中): 优化了具有规定粒径的纯非多晶型结晶胆汁酸的合成
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申请号: US13989012申请日: 2011-11-30
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公开(公告)号: US09512167B2公开(公告)日: 2016-12-06
- 发明人: Rudolf Wilhelm , Markus Proels , Erik Fischer , Heidi Waenerlund Poulsen
- 申请人: Rudolf Wilhelm , Markus Proels , Erik Fischer , Heidi Waenerlund Poulsen
- 申请人地址: DE Freiburg
- 专利权人: Dr. Falk Pharma GmbH
- 当前专利权人: Dr. Falk Pharma GmbH
- 当前专利权人地址: DE Freiburg
- 代理机构: Curatolo Sidoti Co., LPA
- 代理商 Salvatore A. Sidoti; Floyd Trillis, III
- 优先权: EP10193143 20101130
- 国际申请: PCT/EP2011/071406 WO 20111130
- 国际公布: WO2012/072689 WO 20120607
- 主分类号: A61K31/575
- IPC分类号: A61K31/575 ; C07J9/00 ; C07J7/00
摘要:
The present invention relates to a pure polymorph of Nor-UDCA or Bis-nor-UDCA, or of a pharmaceutically acceptable salt thereof. The invention further provides a pharmaceutical composition comprising the polymorph of the invention, and a method for preparing the polymorph. The invention includes the pharmaceutical use of the polymorph or of the pharmaceutical composition of the invention.
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