公开(公告)号：US20140050791A1

公开(公告)日：2014-02-20

申请号：US13989012

申请日：2011-11-30

申请人： Rudolf Wilhelm ,  Markus Proels ,  Erik Fischer ,  Heidi Waenerlund Poulsen

发明人： Rudolf Wilhelm ,  Markus Proels ,  Erik Fischer ,  Heidi Waenerlund Poulsen

IPC分类号： C07J7/00

CPC分类号： C07J9/005 ,  C07B2200/13 ,  C07J7/008 ,  Y10T428/2982

摘要： The present invention relates to a pure polymorph of Nor-UDCA or Bis-nor-UDCA, or of a pharmaceutically acceptable salt thereof. The inventions further provides a pharmaceutical composition comprising the polymorph of the invention, and a method for preparing the polymorph. The invention includes the pharmaceutical use of the polymorph or of the pharmaceutical composition of the invention.

摘要翻译： 本发明涉及Nor-UDCA或Bis-nor-UDCA或其药学上可接受的盐的纯多晶型物。 本发明还提供包含本发明多晶型物的药物组合物和制备该多晶型物的方法。 本发明包括本发明的多晶型物或药物组合物的药物用途。

公开(公告)号：US20080034667A1

公开(公告)日：2008-02-14

申请号：US11891222

申请日：2007-08-09

申请人： Erik Fischer

发明人： Erik Fischer

IPC分类号： B60J5/04

CPC分类号： B60J1/17 ,  B60J1/2086

摘要： A window blind for motor vehicle doors including a winding shaft arranged underneath the window's lower edge is provided. One edge of the blind sheet is fastened to the winding shaft and its other edge is attached to a pull bar. The pull bar is connected to at least one support rod that is arranged approximately at a right angle to the pull bar and projects into the body of the door. The support rod is guided is guided in the body of the door and is provided at its inner end with a dog. The dog is designed to cooperate with the lower pane edge, so that the window blind is also opened semiautomatically when the window is opened.

摘要翻译： 提供了一种用于机动车门的窗帘，包括布置在窗户下边缘下方的卷轴。 盲板的一个边缘固定在卷轴上，其另一个边缘连接到拉杆上。 拉杆连接到至少一个支撑杆，该支撑杆大致与拉杆成直角并且突出到门的主体中。 支撑杆被引导在门的主体中，并且在其内端处设置有狗。 狗被设计成与下部窗格边缘配合，使得窗户在打开窗口时也半自动打开。

公开(公告)号：US20080033032A1

公开(公告)日：2008-02-07

申请号：US11660913

申请日：2005-08-26

申请人： Frederik Beck ,  Erik Fischer

发明人： Frederik Beck ,  Erik Fischer

IPC分类号： A61K31/4015 ,  A61P3/06 ,  C07D207/34

CPC分类号： C07D207/416

摘要： Novel polymorphs Forms I, II and III of the potassium salt of Atorvastatin, (βR,δR)-2-(p-fluorophenyl)-β, δ-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrole-1-heptanoic acid, are obtained directly by precipitation of the potassium salt of Atorvastatin with ethanol (polymorph I), with 1-propanol (polymorph II) and by recrystallisation of polymorph I from 2-propanol (polymorph III).

摘要翻译： 新型多晶型物阿托伐他汀钾盐（βR，δR）-2-（对氟苯基）-β，δ-二羟基-5-异丙基-3-苯基-4-（苯基氨基甲酰基）吡咯-2-羧酸钾盐的形式I， 通过用乙醇（多晶型物I）与1-丙醇（多晶型物II）和通过从2-丙醇（多晶型III）重结晶多晶型物I直接沉淀阿托伐他汀的钾盐，得到1-庚酸。

公开(公告)号：US6060468A

公开(公告)日：2000-05-09

申请号：US943368

申请日：1997-10-03

申请人： Tine Krogh J.o slashed.rgensen ,  Erik Fischer ,  Rolf Hohlweg ,  Knud Erik Andersen ,  Uffe Bang Olsen ,  Zdenek Polivka ,  Vladimir Valenta ,  Karel Sindelar

发明人： Tine Krogh J.o slashed.rgensen ,  Erik Fischer ,  Rolf Hohlweg ,  Knud Erik Andersen ,  Uffe Bang Olsen ,  Zdenek Polivka ,  Vladimir Valenta ,  Karel Sindelar

IPC分类号： A61K31/4523 ,  A61K31/4535 ,  A61P3/08 ,  A61P17/04 ,  A61P25/06 ,  A61P29/00 ,  C07D405/12 ,  C07D409/12 ,  C07D411/06 ,  C07D411/12 ,  C07D491/113 ,  C07D337/14 ,  A61K31/445 ,  C07D211/90

CPC分类号： C07D405/12 ,  C07D409/12 ,  C07D411/12

摘要： The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.1a, R.sup.2, R.sup.2a, p, r and s are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to secretion and circulation of insulin antagonising peptides.

摘要翻译： 本发明涉及以下通式的新的N-取代的氮杂杂环化合物：其中X，Y，Z，R 1，R 1a，R 2，R 2a，p，r和s如在本说明书的详细部分或其盐中所定义， 其制备方法，含有它们的组合物，以及其用于临床治疗疼痛，痛觉过敏和/或炎症状况的用途，其中C纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用以及其用于治疗 由胰岛素拮抗肽分泌和循环引起或与之相关的适应症。

公开(公告)号：US6048856A

公开(公告)日：2000-04-11

申请号：US211378

申请日：1998-12-14

申请人： Tine Krogh J.o slashed.rgensen ,  Erik Fischer ,  Rolf Hohlweg ,  Knud Erik Andersen ,  Uffe Bang Olsen ,  Karel Sindelar ,  Alexandra Silhankova ,  Otylie Konigova ,  Zdenek Polivka

发明人： Tine Krogh J.o slashed.rgensen ,  Erik Fischer ,  Rolf Hohlweg ,  Knud Erik Andersen ,  Uffe Bang Olsen ,  Karel Sindelar ,  Alexandra Silhankova ,  Otylie Konigova ,  Zdenek Polivka

IPC分类号： C07D211/14 ,  C07D211/34 ,  C07D211/64 ,  C07D211/66 ,  C07D401/06 ,  A61K31/55 ,  A61K31/435 ,  C07D211/06 ,  C07D223/18

CPC分类号： C07D401/06 ,  C07D211/14 ,  C07D211/34 ,  C07D211/64 ,  C07D211/66

摘要： The present invention relates to novel N-substituted azaheterocyclic compounds of the formula ##STR1## wherein X, Y, R.sup.1, R.sup.1a, R.sup.2, R.sup.2a, R.sup.12, R.sup.13, A, r and s are as defined in the detailed part of the present description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation. These compounds are also useful for treating indications caused by or related to the secretion and circulation of insulin antagonizing peptides, e.g., non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.

摘要翻译： 本发明涉及下式的新的N-取代的氮杂杂环化合物其中X，Y，R1，R1a，R2，R2a，R12，R13，A，r和s如本说明书的详细部分所定义，或盐 其制备方法，含有它们的组合物，以及其用于临床治疗疼痛，痛觉过敏和/或炎性病症的用途，其中C纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用。 这些化合物还可用于治疗由胰岛素拮抗肽（例如非胰岛素依赖性糖尿病（NIDDM））和老龄化相关性肥胖症引起或与胰岛素拮抗肽分泌和循环有关的适应症。

公开(公告)号：US09512167B2

公开(公告)日：2016-12-06

申请号：US13989012

申请日：2011-11-30

申请人： Rudolf Wilhelm ,  Markus Proels ,  Erik Fischer ,  Heidi Waenerlund Poulsen

发明人： Rudolf Wilhelm ,  Markus Proels ,  Erik Fischer ,  Heidi Waenerlund Poulsen

IPC分类号： A61K31/575 ,  C07J9/00 ,  C07J7/00

CPC分类号： C07J9/005 ,  C07B2200/13 ,  C07J7/008 ,  Y10T428/2982

摘要： The present invention relates to a pure polymorph of Nor-UDCA or Bis-nor-UDCA, or of a pharmaceutically acceptable salt thereof. The invention further provides a pharmaceutical composition comprising the polymorph of the invention, and a method for preparing the polymorph. The invention includes the pharmaceutical use of the polymorph or of the pharmaceutical composition of the invention.

摘要翻译： 本发明涉及Nor-UDCA或Bis-nor-UDCA或其药学上可接受的盐的纯多晶型物。 本发明还提供了包含本发明多晶型物的药物组合物和制备该多晶型物的方法。 本发明包括本发明的多晶型物或药物组合物的药物用途。

公开(公告)号：US20120197263A1

公开(公告)日：2012-08-02

申请号：US13220499

申请日：2011-08-29

申请人： Franz Copf ,  Marcus Mohr ,  Lino Taddia ,  Erik Fischer ,  Tomislav Anic ,  Gerhard Pross

发明人： Franz Copf ,  Marcus Mohr ,  Lino Taddia ,  Erik Fischer ,  Tomislav Anic ,  Gerhard Pross

IPC分类号： A61B17/56

CPC分类号： A61F2/4611 ,  A61B2017/0256 ,  A61F2/30771 ,  A61F2/446 ,  A61F2002/30207 ,  A61F2002/30227 ,  A61F2002/3023 ,  A61F2002/30598 ,  A61F2002/30784 ,  A61F2002/30785 ,  A61F2002/30858 ,  A61F2002/30863 ,  A61F2002/30874 ,  A61F2002/30886 ,  A61F2002/4623 ,  A61F2002/4624 ,  A61F2002/4627 ,  A61F2002/4628 ,  A61F2002/4629 ,  A61F2002/4662

摘要： An instrument set for screwing an implant into an intervertebral disc space comprises a guide sleeve and a screwing-in instrument. The latter has a shank having a distal end at which the implant can be fixed in a rotationally rigid manner. At the proximal end a rotary handle is fastened in a rotationally rigid manner. The screwing-in instrument further has a residual-advance indicator, which is configured to quantitatively indicate to the surgeon, during the screwing-in procedure, how far the implant is distant in the axial direction from an axial specified position that is fixed relative to the location at which the guide sleeve is supported on the vertebrae.

摘要翻译： 用于将植入物旋入椎间盘空间的仪器组件包括导向套筒和旋入器械。 后者具有柄，其具有远端，植入物可以以旋转刚性的方式固定在该远端上。 在近端处，旋转手柄以旋转刚性方式固定。 螺纹连接仪器还具有残余提前指示器，其被配置成在旋拧过程期间向外科医生定量地指示植入物在轴向方向上距离相对于固定的轴向指定位置有多远 引导套筒支撑在椎骨上的位置。

公开(公告)号：US6114354A

公开(公告)日：2000-09-05

申请号：US375745

申请日：1999-08-17

申请人： Knud Erik Andersen ,  Tine Krogh J.o slashed.rgensen ,  Rolf Hohlweg ,  Erik Fischer ,  Uffe Bang Olsen ,  Zdenek Polivka ,  Karel Sindelar ,  Vladimir Valenta

发明人： Knud Erik Andersen ,  Tine Krogh J.o slashed.rgensen ,  Rolf Hohlweg ,  Erik Fischer ,  Uffe Bang Olsen ,  Zdenek Polivka ,  Karel Sindelar ,  Vladimir Valenta

IPC分类号： C07D211/34 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06 ,  C07D211/62 ,  A61K31/445 ,  C07D211/60

CPC分类号： C07D401/06 ,  C07D211/34 ,  C07D405/06 ,  C07D409/06

摘要： The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the present description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neuragenic pain or inflammation as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.

摘要翻译： 本发明涉及以下通式的新的N-取代的氮杂杂环化合物：其中X，Y，Z，R 1，R 2和r如在本说明书的详细部分中所定义，或其盐，其制备方法， 含有它们的组合物，以及其用于临床治疗疼痛，痛觉过敏和/或炎性病症的用途，其中C纤维通过引发神经痛或炎症而发挥病理生理学作用，以及其用于治疗由或由 胰岛素拮抗肽的分泌和循环，例如 非胰岛素依赖性糖尿病（NIDDM）和衰老相关性肥胖。

公开(公告)号：US6100253A

公开(公告)日：2000-08-08

申请号：US376734

申请日：1999-08-17

申请人： Knud Erik Andersen ,  Tine Krogh J.o slashed.rgensen ,  Rolf Hohlweg ,  Erik Fischer ,  Uffe Bang Olsen ,  Zdenek Polivka ,  Karel Sindelar ,  Vladimir Valenta

发明人： Knud Erik Andersen ,  Tine Krogh J.o slashed.rgensen ,  Rolf Hohlweg ,  Erik Fischer ,  Uffe Bang Olsen ,  Zdenek Polivka ,  Karel Sindelar ,  Vladimir Valenta

IPC分类号： C07D211/34 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06 ,  A61K31/55 ,  A61K31/445 ,  C07D211/06 ,  C07D307/48 ,  C07J21/00

CPC分类号： C07D401/06 ,  C07D211/34 ,  C07D405/06 ,  C07D409/06

摘要： The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the present description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.

摘要翻译： 本发明涉及以下通式的新的N-取代的氮杂杂环化合物：其中X，Y，Z，R 1，R 2和r如在本说明书的详细部分中所定义，或其盐，其制备方法， 含有它们的组合物，以及它们用于临床治疗疼痛，痛觉过敏和/或炎性病症的用途，其中C纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用，以及它们用于治疗由或由 胰岛素拮抗肽的分泌和循环，例如 非胰岛素依赖性糖尿病（NIDDM）和衰老相关性肥胖。

公开(公告)号：US20080034668A1

公开(公告)日：2008-02-14

申请号：US11891275

申请日：2007-08-09

申请人： Erik Fischer

发明人： Erik Fischer

IPC分类号： B60J5/04

CPC分类号： B60J1/2027 ,  B60J1/2086

摘要： A window blind for motor vehicle doors including a winding shaft arranged underneath the window's lower edge is provided. One edge of the blind sheet is fastened to the winding shaft and its other edge is attached to a pull bar. The pull bar is connected to at least one support rod that is arranged approximately at a right angle to the pull bar and projects into the body of the door. The support rod is guided in the door body and it is provided at its inner end with a dog. The dog is designed to cooperate with a dog driven by the window lifter, so that the window blind is also opened semiautomatically when the window is opened.

摘要翻译： 提供了一种用于机动车门的窗帘，包括布置在窗户下边缘下方的卷轴。 盲板的一个边缘固定在卷轴上，其另一个边缘连接到拉杆上。 拉杆连接到至少一个支撑杆，该支撑杆大致与拉杆成直角并且突出到门的主体中。 支撑杆在门体内引导，其内端设有一只狗。 狗被设计成与由窗户升降机驱动的狗配合，使得窗户在打开窗户时半自动地打开。