发明授权
US09526767B2 Pharmaceutical composition comprising bee venom-phospholipase A2 (BV-PLA2) for treating or preventing diseases related to degradation of abnormal regulatory T cell activity
有权
包含用于治疗或预防与异常调节性T细胞活性降解有关的疾病的蜂毒素磷脂酶A2（BV-PLA2）的药物组合物
- 专利标题： Pharmaceutical composition comprising bee venom-phospholipase A2 (BV-PLA2) for treating or preventing diseases related to degradation of abnormal regulatory T cell activity
- 专利标题（中）： 包含用于治疗或预防与异常调节性T细胞活性降解有关的疾病的蜂毒素磷脂酶A2（BV-PLA2）的药物组合物
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申请号： US14381095申请日： 2012-06-04
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公开(公告)号： US09526767B2公开(公告)日： 2016-12-27
- 发明人: Hyun Su Bae , Hyo Jung Lee , Gi Hyun Lee , Hyun Seong Kim , Soo Jin Park , Eun Sook Chung , Tae Won Choi
- 申请人： Hyun Su Bae , Hyo Jung Lee , Gi Hyun Lee , Hyun Seong Kim , Soo Jin Park , Eun Sook Chung , Tae Won Choi
- 申请人地址： KR Gyeonggi-do
- 专利权人： UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY
- 当前专利权人： UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY
- 当前专利权人地址： KR Gyeonggi-do
- 代理机构： Gavrilovich, Dodd & Lindsey LLP
- 代理商 Joseph R. Baker, Jr.
- 优先权： KR10-2012-0019925 20120227
- 国际申请： PCT/KR2012/004394 WO 20120604
- 国际公布： WO2013/129739 WO 20130906
- 主分类号： A61P25/28
- IPC分类号： A61P25/28 ; A61K38/46 ; C12N9/20
摘要：
The present invention relates to a pharmaceutical composition for treating or preventing a disease related to abnormal suppression of regulatory T cell activity comprising a polypeptide comprising a bee venom-PLA2 amino acid sequence exclusive of a leader sequence as an active ingredient. The secretory bee venom-phospholipase A2 of the present invention activates a regulatory T cell and suppress a differentiation of Th1/Th7. Therefore, the present polypeptide can be used as a pharmaceutical composition for treating or preventing a disease related to abnormal suppression of regulatory T cell activity, i.e. autoimmune diseases, allergic diseases, or neurodegenerative diseases.
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