发明授权
US09527803B2 Crystal form VII of agomelatine, preparation method and use thereof and pharmaceutical composition containing same
有权
琼脂糖凝胶晶形VII，其制备方法和用途以及含有它们的药物组合物
- 专利标题： Crystal form VII of agomelatine, preparation method and use thereof and pharmaceutical composition containing same
- 专利标题（中）： 琼脂糖凝胶晶形VII，其制备方法和用途以及含有它们的药物组合物
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申请号： US14006468申请日： 2012-03-22
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公开(公告)号： US09527803B2公开(公告)日： 2016-12-27
- 发明人: Yu Huang , Ling Tong , Xueyan Zhu , Hanbin Shan , Zhedong Yuan , Xiong Yu
- 申请人： Yu Huang , Ling Tong , Xueyan Zhu , Hanbin Shan , Zhedong Yuan , Xiong Yu
- 申请人地址： FR Suresnes Cedex CN Jing'an District, Shanghai
- 专利权人： LES LABORATOIRES SERVIER,SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY
- 当前专利权人： LES LABORATOIRES SERVIER,SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY
- 当前专利权人地址： FR Suresnes Cedex CN Jing'an District, Shanghai
- 代理机构： Hueschen and Sage
- 优先权： CN201110070828 20110323
- 国际申请： PCT/CN2012/072816 WO 20120322
- 国际公布： WO2012/126385 WO 20120927
- 主分类号： C07C231/24
- IPC分类号： C07C231/24 ; C07C233/22 ; A61K9/48
摘要：
The present invention provides a new crystalline form VII of agomelatine, its method of preparation, application and pharmaceutical composition. This new crystalline form offers high purity, a stable crystalline structure and good reproducibility, while its method of production lends itself well to large scale production. In terms of stability and purity, it is superior to the numerous crystalline forms which have hitherto been reported. As a result, the crystalline form VII of the present invention possesses advantages in pharmaceutical preparation.
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