Invention Grant
US09527871B2 Benzodiazepine dimers, conjugates thereof, and methods of making and using
有权
苯并二氮杂二聚体，其偶联物，以及制备和使用方法
- Patent Title: Benzodiazepine dimers, conjugates thereof, and methods of making and using
- Patent Title (中): 苯并二氮杂二聚体，其偶联物，以及制备和使用方法
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Application No.: US14994296Application Date: 2016-01-13
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Publication No.: US09527871B2Publication Date: 2016-12-27
- Inventor: Yong Zhang , Ivar M. McDonald , Naidu S. Chowdari , Tram N. Huynh , Robert M. Borzilleri , Sanjeev Gangwar
- Applicant: Bristol-Myers Squibb Company
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agent Yuan Chao
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D519/00 ; A61K47/48 ; C07K16/18 ; C07K16/28 ; C07K16/30
Abstract:
Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
Public/Granted literature
- US20160200742A1 BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING Public/Granted day:2016-07-14
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