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公开(公告)号：US10889590B2
公开(公告)日：2021-01-12
申请号：US16357109
申请日：2019-03-18
发明人： Kyriacos C. Nicolaou , Min Lu , Debashis Mandal , Sanjeev Gangwar , Naidu S. Chowdari , Yam B. Poudel
IPC分类号： C07D491/08 , A61K47/68
摘要： In one aspect, the present disclosure provides new analogs of uncialamycin. The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates which may be used to treat cancer or another disease or disorder.
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公开(公告)号：US09822144B2
公开(公告)日：2017-11-21
申请号：US15587715
申请日：2017-05-05
发明人： Yong Zhang , Ivar M. McDonald , Naidu S. Chowdari , Tram N. Huynh , Robert M. Borzilleri , Sanjeev Gangwar
IPC分类号： C07D487/04 , C07D519/00 , C07K5/062
CPC分类号： C07K5/06052 , A61K47/6843 , A61K47/6849 , C07D487/04 , C07D519/00 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/76
摘要： Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
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3.发明申请ENEDIYNE COMPOUNDS, CONJUGATES THEREOF, AND USES AND METHODS THEREFOR 审中-公开ENEDIYNE化合物，其结合物及其用途及其用途公开(公告)号：US20140193438A1
公开(公告)日：2014-07-10
申请号：US14203118
申请日：2014-03-10
发明人： Naidu S. Chowdari , Sanjeev Gangwar , Bilal Sufi
IPC分类号： C07D491/08 , A61K31/439 , A61K47/48
CPC分类号： C07D491/08 , A61K31/439 , A61K47/48384 , A61K47/6803 , C07K16/18
摘要： Enediyne compounds having a structure according to formula (I), where R0, R2, R3, R4, R5, R6, and R7 are defined herein, can be used in chemotherapeutic drugs, especially in conjugates, for the treatment of diseases such as cancer.
摘要翻译： 具有式（I）结构的烯二烯化合物，其中R 0，R 2，R 3，R 4，R 5，R 6和R 7在本文中定义，可用于化疗药物，特别是缀合物用于治疗疾病如癌症 。
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公开(公告)号：US08709431B2
公开(公告)日：2014-04-29
申请号：US13764226
申请日：2013-02-11
发明人： Naidu S. Chowdari , Sanjeev Gangwar , Bilal Sufi
IPC分类号： A61K39/00 , C07D489/12 , C07D491/00 , C07D498/00 , C07D513/00 , C07D515/00 , A61K31/44 , A01N43/42 , C07K16/00 , C12P21/08
CPC分类号： C07D491/08 , A61K31/439 , A61K47/48384 , A61K47/6803 , C07K16/18
摘要： Enediyne compounds having a structure according to formula (I), where R0, R2, R3, R4, R5, R6, and R7 are defined herein, can be used in chemotherapeutic drugs, especially in conjugates, for the treatment of diseases such as cancer.
摘要翻译： 具有式（I）结构的烯二烯化合物，其中R 0，R 2，R 3，R 4，R 5，R 6和R 7在本文中定义，可用于化疗药物，特别是缀合物用于治疗疾病如癌症 。
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公开(公告)号：US11485741B2
公开(公告)日：2022-11-01
申请号：US17043886
申请日：2019-04-23
发明人： Ashok V. Purandare , Honghe Wan , Liqi He , Sanjeev Gangwar , Shoshana L. Posy , Yam B. Poudel , Prasanna Sivaprakasam , Naidu S. Chowdari
IPC分类号： C07D487/16 , A61K47/60
摘要： Compounds having a structure according to formula are modulators of TLR7 activity and can be used to treat conditions amenable to treatment by the modulation of TLR7 activity.
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公开(公告)号：US10112975B2
公开(公告)日：2018-10-30
申请号：US15785675
申请日：2017-10-17
发明人： Yong Zhang , Ivar M. McDonald , Naidu S. Chowdari , Tram N. Huynh , Robert M. Borzilleri , Sanjeev Gangwar
IPC分类号： C07D487/04 , C07D519/00 , C07K5/062
摘要： Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
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公开(公告)号：US09777013B2
公开(公告)日：2017-10-03
申请号：US14911881
申请日：2014-08-14
发明人： Kyriacos C. Nicolaou , Min Lu , Debashis Mandal , Sanjeev Gangwar , Naidu S. Chowdari , Yam B. Poudel
IPC分类号： C07D491/08 , A61K47/48
CPC分类号： C07D491/08 , A61K47/6803 , A61K47/6851
摘要： In one aspect, the present disclosure provides new analogs of uncialamycin of formulae (I) and (II). The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates comprising the compounds of formulae (I) and (II).
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公开(公告)号：US09676794B2
公开(公告)日：2017-06-13
申请号：US15351843
申请日：2016-11-15
发明人： Yong Zhang , Ivar M. McDonald , Naidu S. Chowdari , Tram N. Huynh , Robert M. Borzilleri , Sanjeev Gangwar
IPC分类号： C07D487/04 , C07D519/00
CPC分类号： C07K5/06052 , A61K47/6843 , A61K47/6849 , C07D487/04 , C07D519/00 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/76
摘要： Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
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9.发明授权公开(公告)号：US09676775B2
公开(公告)日：2017-06-13
申请号：US15351955
申请日：2016-11-15
发明人： Ivar M. McDonald , Naidu S. Chowdari , Walter Lewis Johnson , Yong Zhang , Robert M. Borzilleri , Sanjeev Gangwar
IPC分类号： C07D487/04 , C07D519/00 , C07D471/04
CPC分类号： C07D471/04 , A61K47/6803 , A61K47/6851 , A61K47/6889 , C07D487/04 , C07D519/00 , C07K5/06052
摘要： Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
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10.发明授权Benzodiazepine dimers, conjugates thereof, and methods of making and using 有权苯并二氮杂二聚体，其偶联物，以及制备和使用方法公开(公告)号：US09527871B2
公开(公告)日：2016-12-27
申请号：US14994296
申请日：2016-01-13
发明人： Yong Zhang , Ivar M. McDonald , Naidu S. Chowdari , Tram N. Huynh , Robert M. Borzilleri , Sanjeev Gangwar
IPC分类号： C07D487/04 , C07D519/00 , A61K47/48 , C07K16/18 , C07K16/28 , C07K16/30
CPC分类号： C07K5/06052 , A61K47/6843 , A61K47/6849 , C07D487/04 , C07D519/00 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/76
摘要： Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
摘要翻译： 具有由其中R1表示的结构的苯并二氮杂二聚体，其中式（I），（Ia）和（Ib）中的变量如本申请中所定义。 这种二聚体可用作抗癌剂，特别是当用于抗体 - 药物偶联物（ADC）时。
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