Systems, methods, and machine-readable media transitioning between two power states based on user-related signals are provided. A computing device in a first power state may monitor multiple sensors and receive first sensor signals from a first group of the sensors. One or more radio frequency (RF) signals may be received from one or more nearby communication devices. The first sensor signals may be used to determine that the computing device has been picked up and, in response, an application processor maybe activated. The application processor may select a second power state based on the first power state and the first sensor signals. The second power state includes a power on state when the first power state is a suspended power state and the first sensor signals indicate that the computing device has been picked up while being touched on a screen. The computing device is transitioned to the second power state.