Two-handed interactions with a natural user interface are disclosed. For example, one embodiment provides a method comprising detecting via image data received by the computing device a context-setting input performed by a first hand of a user, and sending to a display a user interface positioned based on a virtual interaction coordinate system, the virtual coordinate system being positioned based upon a position of the first hand of the user. The method further includes detecting via image data received by the computing device an action input performed by a second hand of the user, the action input performed while the first hand of the user is performing the context-setting input, and sending to the display a response based on the context-setting input and an interaction between the action input and the virtual interaction coordinate system.