Invention Grant
- Patent Title: Anti-Aβ globulomer 7C6 antibodies
- Patent Title (中): 抗Aβ球寡糖7C6抗体
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Application No.: US13893780Application Date: 2013-05-14
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Publication No.: US09540432B2Publication Date: 2017-01-10
- Inventor: Stefan Barghorn , Heinz Hillen , Boris Labkovsky , Andreas R. Striebinger , Patrick Keller , Ulrich Ebert
- Applicant: ABBVIE INC. , ABBVIE DEUTSCHLAND GMBH & CO. KG
- Applicant Address: DE Wiesbaden US IL North Chicago
- Assignee: ABBVIE DEUTSCHLAND GMBH & CO. KG,ABBVIE INC.
- Current Assignee: ABBVIE DEUTSCHLAND GMBH & CO. KG,ABBVIE INC.
- Current Assignee Address: DE Wiesbaden US IL North Chicago
- Agency: Neal, Gerber & Eisenberg LLP
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C07K16/18 ; C07K14/47 ; A61K38/00

Abstract:
Anti-Aβ globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies.The present invention relates to anti-Aβ globulomer antibodies having a binding affinity to Aβ(20-42) globulomer that is greater than the binding affinity of the antibody to Aβ(1-42) globulomer, antigen-binding moieties thereof, hybridomas producing said antibodies, nucleic acids encoding said antibodies, vectors comprising said nucleic acids, host cells comprising said vectors, methods of producing said antibodies, compositions comprising said antibodies, therapeutic and diagnostic uses of said antibodies and corresponding methods relating to Alzheimer's disease and other amyloidoses.
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