Provided are a method and a system for initializing an RF module through non-volatile control, including: storing, by a non-volatile storage array, configuration information for initializing the RF module, and backing up the configuration information when receiving a power-down instruction (S1); and reading, by an RF module initialization accelerator, the configuration information from the non-volatile storage array when receiving a power-up instruction, and transmitting the read configuration information to the RF module, thereby initializing the RF module (S2). With the technical solution given in the present invention, the initialization of an RF module becomes much faster, and the power consumption of a wireless communication terminal can be reduced. In addition, the initialization of various RF modules can be supported, and meanwhile the hardware resources can be saved, thereby enhancing the extensibility of the system.