The method comprising at least one user device provided with at least four antennas, wirelessly connected to a serving base station having between one and four transmit antennas and suffering interferences from at least one interfering base station having between one and four transmit antennas, establishing a data transmission link among a plurality of antennas, and: applying a time shift delay between said serving base station and said at least one interfering base station in order to avoid collision between Cell Reference Signals (CRS) of serving and interfering base stations when said data transmission is established; and introducing changes on the physical layer for PDSCH transmission and reception aimed at achieving inter-layer interference cancellation, said changes introduced comprising the introduction of a pattern of transmission gaps at symbols (l) and subcarrier indices (k) of interfering cell's CRS signals, which will be exploited by said at least one user device for effective interference cancellation.