A method for optimizing uplink power control settings in a wireless network, the method comprising generating a first gene pool comprising a set of parent genes, wherein each parent gene comprises a set of first generation power control solutions for a set of base stations in the wireless network. The method may further include performing natural selection on the first gene pool to generate a second gene pool comprising selected ones of the set of parent genes, wherein the selected parent genes are chosen by probabilistically selecting some of the parent genes based on fitness values assigned to the parent genes. The method may further include evolving the second gene pool into a descendent gene, wherein the descendent gene comprises a set of local power control solutions for the set of base station in the wireless network.