The present invention provides an uplink MU-MIMO method. The method includes: sending, by a user equipment, a sounding reference signal to a base station, so that the base station constructs a precoding matrix according to the sounding reference signal, and generates a first scheduling message according to the precoding matrix; receiving the first scheduling message sent by the base station, where the first scheduling message includes a layer mapping rule and the precoding matrix; generating at least one MAC packet data unit MAC PDU according to the first scheduling message, and sending the MAC PDU, so that multiple user equipments exchange the MAC PDUs; generating an uplink signal after the MAC PDU is processed in various layers; and sending, by using an antenna, the uplink signal to the base station. The present invention greatly improves uplink spectral efficiency of a system.