Invention Grant
US09556180B2 Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the P53/MDM2 interaction
有权
吡唑并[3,4-d]嘧啶酮化合物作为P53 / MDM2相互作用的抑制剂
![Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the P53/MDM2 interaction](/docs/US/2017-01-31/US09556180B2/abs.jpg.600x600.jpg)
- Patent Title: Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the P53/MDM2 interaction
- Patent Title (中): 吡唑并[3,4-d]嘧啶酮化合物作为P53 / MDM2相互作用的抑制剂
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Application No.: US14762051Application Date: 2014-01-21
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Publication No.: US09556180B2Publication Date: 2017-01-31
- Inventor: Pascal Furet , Vito Guagnano , Philipp Holzer , Joerg Kallen , Robert Mah , Keiichi Masuya , Achim Schlapbach , Andrea Vaupel
- Applicant: Novartis AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Qian Zhang
- International Application: PCT/IB2014/058442 WO 20140121
- International Announcement: WO2014/115080 WO 20140731
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/519
![Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the P53/MDM2 interaction](/abs-image/US/2017/01/31/US09556180B2/abs.jpg.150x150.jpg)
Abstract:
The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.
Public/Granted literature
- US20150353563A1 PYRAZOLO[3,4-D]PYRIMIDINONE COMPOUNDS AS INHIBITORS OF THE P53/MDM2 INTERACTION Public/Granted day:2015-12-10
Information query
