公开(公告)号：US09556180B2

公开(公告)日：2017-01-31

申请号：US14762051

申请日：2014-01-21

申请人： Novartis AG

发明人： Pascal Furet ,  Vito Guagnano ,  Philipp Holzer ,  Joerg Kallen ,  Robert Mah ,  Keiichi Masuya ,  Achim Schlapbach ,  Andrea Vaupel

IPC分类号： C07D487/04 ,  A61K31/519

CPC分类号： C07D487/04 ,  A61K31/519

摘要： The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.

摘要翻译： 本发明涉及式（I）化合物：如本文所述，包含这些化合物的药物制剂，用于治疗由MDM2和/或MDM4的活性介导的疾病或疾病的这些化合物的用途和方法，以及 包含这些化合物的组合。

公开(公告)号：US11541056B2

公开(公告)日：2023-01-03

申请号：US16981208

申请日：2019-03-25

申请人： NOVARTIS AG

发明人： Luca Arista ,  Christina Hebach ,  Gregory John Hollingworth ,  Philipp Holzer ,  Patricia Imbach-Weese ,  Rainer Machauer ,  Niko Schmiedeberg ,  Anna Vulpetti ,  Thomas Zoller

IPC分类号： C07D519/00 ,  C07D487/04 ,  A61K31/519 ,  A61P35/00

摘要： The invention relates to compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

公开(公告)号：US11878973B2

公开(公告)日：2024-01-23

申请号：US17824407

申请日：2022-05-25

申请人： NOVARTIS AG

发明人： Vincent Bordas ,  Jvan Brun ,  Markus Furegati ,  Jacques Hamon ,  Jürgen Hans-Hermann Hinrichs ,  Philipp Holzer ,  Fatma Limam ,  Henrik Möbitz ,  Sandro Nocito ,  Simone Plattner ,  Niko Schmiedeberg ,  Joseph Schoepfer ,  Ross Sinclair Strang ,  Frédéric Zecri

IPC分类号： C07D413/14 ,  C07D401/14 ,  C07D405/14

CPC分类号： C07D413/14 ,  C07D401/14 ,  C07D405/14 ,  C07B2200/13

摘要： The present invention provides a compound, or a pharmaceutically acceptable salt thereof, of formula (I):




wherein R1, R2, R3, R4, R5, R26, R27, y, R, M, W, L, V, T, Y, J, K and A are as described herein, therapeutic uses of said compounds, uses of said compounds as research chemicals, a pharmaceutical composition and combinations comprising said compounds, and methods for manufacturing the compounds of the invention.

公开(公告)号：US20210251996A1

公开(公告)日：2021-08-19

申请号：US16981208

申请日：2019-03-25

申请人： NOVARTIS AG

发明人： Luca Arista ,  Christina Hebach ,  Gregory John Hollingworth ,  Philipp Holzer ,  Patricia Imbach-Weese ,  Rainer Machauer ,  Niko Schmiedeberg ,  Anna Vulpetti ,  Thomas Zoller

IPC分类号： A61K31/519 ,  C07D519/00 ,  C07D487/04 ,  A61P35/00

摘要： The invention relates to compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

公开(公告)号：US09051279B2

公开(公告)日：2015-06-09

申请号：US13778910

申请日：2013-02-27

申请人： Novartis AG

发明人： Joerg Berghausen ,  Nicole Buschmann ,  Pascal Furet ,  Francois Gessier ,  Joanna Hergovich Lisztwan ,  Philipp Holzer ,  Edgar Jacoby ,  Joerg Kallen ,  Keiichi Masuya ,  Carole Pissot Soldermann ,  Haixia Ren ,  Stefan Stutz

IPC分类号： C07D239/82 ,  A01N43/54 ,  A61K31/517 ,  C07D217/24 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

CPC分类号： C07D239/82 ,  C07D217/24 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) wherein Z is CH2 or N—R4 and X, R1, R2, R4, R6, R7 and n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.

摘要翻译： 本发明涉及式（I）的取代的含氮双环杂环，其中Z是CH 2或N-R 4，X，R 1，R 2，R 4，R 6，R 7和n如说明书中所定义。 这些化合物适用于治疗由MDM2和/或MDM4或其变体的活性介导的病症或疾病。

公开(公告)号：US20140350010A1

公开(公告)日：2014-11-27

申请号：US14361068

申请日：2012-11-28

申请人： NOVARTIS AG

发明人： Pascal Furet ,  Vito Guagnano ,  Philipp Holzer ,  Robert Mah ,  Keiichi Masuya ,  Achim Schlapbach ,  Stefan Stutz ,  Andrea Vaupel

IPC分类号： C07D487/04 ,  A61K31/4178 ,  A61K31/4162 ,  A61K31/4709 ,  A61K31/506 ,  A61K31/41 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/4439 ,  A61K31/519

CPC分类号： C07D487/04 ,  A61K31/41 ,  A61K31/4162 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377

摘要： The invention relates to compounds of formula (I) as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.

摘要翻译： 本发明涉及本文所述的式（I）化合物，包含这些化合物的药物制剂，用于治疗由MDM2和/或MDM4的活性介导的疾病或疾病的化合物的用途和用途，以及组合 包括这样的化合物。

公开(公告)号：US08815926B2

公开(公告)日：2014-08-26

申请号：US13748790

申请日：2013-01-24

申请人： Novartis AG

发明人： Pascal Furet ,  Vito Guagnano ,  Philipp Holzer ,  Joerg Kallen ,  Lv Liao ,  Robert Mah ,  Liang Mao ,  Keiichi Masuya ,  Achim Schlapbach ,  Stefan Stutz ,  Andrea Vaupel

IPC分类号： A61K31/4188 ,  C07D235/02 ,  C07D487/04 ,  A61K45/06 ,  A61K31/541 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/501

CPC分类号： C07D487/04 ,  A61K31/4188 ,  A61K31/4439 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06

摘要： The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.

摘要翻译： 本发明涉及式（I）化合物：如本文所述，包含这些化合物的药物制剂，用于治疗由MDM2和/或MDM4的活性介导的疾病或疾病的这些化合物的用途和方法，以及 包含这些化合物的组合。

公开(公告)号：US11613543B2

公开(公告)日：2023-03-28

申请号：US16981059

申请日：2019-03-22

申请人： NOVARTIS AG

发明人： Luca Arista ,  Christina Hebach ,  Gregory John Hollingworth ,  Philipp Holzer ,  Patricia Imbach-Weese ,  Julien Lorber ,  Rainer Machauer ,  Niko Schmiedeberg ,  Anna Vulpetti ,  Thomas Zoller

IPC分类号： A61K31/519 ,  C07D487/04 ,  C07D519/00 ,  A61K45/06

摘要： The invention relates to compounds of the formula (I) (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

公开(公告)号：US20210002285A1

公开(公告)日：2021-01-07

申请号：US16981059

申请日：2019-03-22

申请人： NOVARTIS AG

发明人： Luca Arista ,  Christina Hebach ,  Gregory John Hollingworth ,  Philipp Holzer ,  Patricia Imbach-Weese ,  Julien Lorber ,  Rainer Machauer ,  Niko Schmiedeberg ,  Anna Vulpetti ,  Thomas Zoller

IPC分类号： C07D487/04 ,  C07D519/00

摘要： The invention relates to compounds of the formula (I) (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.