Invention Grant
US09556204B2 Methods and intermediates for the preparation of (4bS,5aR)-12-cyclohexyl-N-(N,N-dimethylsulfamoyl)-3-methoxy-5a-((1R,5S)-3-methyl-3,8-diazabicyclo [3.2.1]octane-8-carbonyl)-4b,5,5a,6-tetrahydrobenzo [3,4]cyclopropa[5,6]azepino[1,2-A]indole-9-carboxamide
有权
制备（4bS，5R）-12-环己基-N-（N，N-二甲基氨磺酰基）-3-甲氧基-5a - （（1R，5S）-3-甲基-3,8-二氮杂双环[ 3.2.1]辛烷-8-羰基）-4b，5,5a，6-四氢苯并[3,4]环丙并[5,6]氮杂环庚烯并[1,2-A]吲哚-9-甲酰胺
![Methods and intermediates for the preparation of (4bS,5aR)-12-cyclohexyl-N-(N,N-dimethylsulfamoyl)-3-methoxy-5a-((1R,5S)-3-methyl-3,8-diazabicyclo [3.2.1]octane-8-carbonyl)-4b,5,5a,6-tetrahydrobenzo [3,4]cyclopropa[5,6]azepino[1,2-A]indole-9-carboxamide](/docs/US/2017-01-31/US09556204B2/abs.jpg.600x600.jpg)
- Patent Title: Methods and intermediates for the preparation of (4bS,5aR)-12-cyclohexyl-N-(N,N-dimethylsulfamoyl)-3-methoxy-5a-((1R,5S)-3-methyl-3,8-diazabicyclo [3.2.1]octane-8-carbonyl)-4b,5,5a,6-tetrahydrobenzo [3,4]cyclopropa[5,6]azepino[1,2-A]indole-9-carboxamide
- Patent Title (中): 制备（4bS，5R）-12-环己基-N-（N，N-二甲基氨磺酰基）-3-甲氧基-5a - （（1R，5S）-3-甲基-3,8-二氮杂双环[ 3.2.1]辛烷-8-羰基）-4b，5,5a，6-四氢苯并[3,4]环丙并[5,6]氮杂环庚烯并[1,2-A]吲哚-9-甲酰胺
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Application No.: US14414475Application Date: 2013-07-16
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Publication No.: US09556204B2Publication Date: 2017-01-31
- Inventor: Albert J. DelMonte , Kenneth J. Natalie, Jr. , Kenneth J. Fraunhoffer , Christina Ann Risatti , Chao Hang , Zhinong Gao , Akin H. Davulcu , Wenhao Hu
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent James Epperson
- International Application: PCT/US2013/050640 WO 20130716
- International Announcement: WO2014/014885 WO 20140123
- Main IPC: C07C62/10
- IPC: C07C62/10 ; C07C69/734 ; C07C69/757 ; C07D209/08 ; C07D487/04 ; C07D519/00 ; C07C211/45 ; C07C233/05
![Methods and intermediates for the preparation of (4bS,5aR)-12-cyclohexyl-N-(N,N-dimethylsulfamoyl)-3-methoxy-5a-((1R,5S)-3-methyl-3,8-diazabicyclo [3.2.1]octane-8-carbonyl)-4b,5,5a,6-tetrahydrobenzo [3,4]cyclopropa[5,6]azepino[1,2-A]indole-9-carboxamide](/abs-image/US/2017/01/31/US09556204B2/abs.jpg.150x150.jpg)
Abstract:
The present invention provides methods and intermediates for the preparation of (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide (formula I), including pharmaceutically acceptable salts. The compound has activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
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