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![Methods and intermediates for the preparation of (4bS,5aR)-12-cyclohexyl-N-(N,N-dimethylsulfamoyl)-3-methoxy-5a-((1R,5S)-3-methyl-3,8-diazabicyclo [3.2.1]octane-8-carbonyl)-4b,5,5a,6-tetrahydrobenzo [3,4]cyclopropa[5,6]azepino[1,2-A]indole-9-carboxamide](/abs-image/US/2017/01/31/US09556204B2/abs.jpg.150x150.jpg)
1.发明授权Methods and intermediates for the preparation of (4bS,5aR)-12-cyclohexyl-N-(N,N-dimethylsulfamoyl)-3-methoxy-5a-((1R,5S)-3-methyl-3,8-diazabicyclo [3.2.1]octane-8-carbonyl)-4b,5,5a,6-tetrahydrobenzo [3,4]cyclopropa[5,6]azepino[1,2-A]indole-9-carboxamide 有权制备（4bS，5R）-12-环己基-N-（N，N-二甲基氨磺酰基）-3-甲氧基-5a - （（1R，5S）-3-甲基-3,8-二氮杂双环[ 3.2.1]辛烷-8-羰基）-4b，5,5a，6-四氢苯并[3,4]环丙并[5,6]氮杂环庚烯并[1,2-A]吲哚-9-甲酰胺公开(公告)号：US09556204B2
公开(公告)日：2017-01-31
申请号：US14414475
申请日：2013-07-16
发明人： Albert J. DelMonte , Kenneth J. Natalie, Jr. , Kenneth J. Fraunhoffer , Christina Ann Risatti , Chao Hang , Zhinong Gao , Akin H. Davulcu , Wenhao Hu
IPC分类号： C07C62/10 , C07C69/734 , C07C69/757 , C07D209/08 , C07D487/04 , C07D519/00 , C07C211/45 , C07C233/05
CPC分类号： C07D519/00 , C07C62/10 , C07C69/734 , C07C69/757 , C07C211/45 , C07C233/05 , C07D209/08 , C07D487/04
摘要： The present invention provides methods and intermediates for the preparation of (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide (formula I), including pharmaceutically acceptable salts. The compound has activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
摘要翻译： 本发明提供了制备（1aR，12bS）-8-环己基-11-氟-N（（1-甲基环丙基）磺酰基）-1a - （（3-甲基-3,8-二氮杂双环[ 3.2.1]辛-8-基）羰基）-1,1a，2,12b-四氢环丙[d]吲哚并[2,1-a] [2]苯并氮杂-5-甲酰胺（式I），包括药学上可接受的盐 。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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公开(公告)号：US20220064205A1
公开(公告)日：2022-03-03
申请号：US17299087
申请日：2019-12-03
发明人： Michael Anthony Schmidt , Bin Zheng Kendall Park , Benjamin M. Cohen , Amanda J. Rogers , Changxia Yuan Warren , Jason J. Zhu , Chao Hang , Daniel S. Treitler , Adam Josep Freitag , Geoffrey Eugene Purdum , Miao Yu , Melda Sezen Edmonds , Siwei Guo
摘要： The invention generally relates to an improved processes for the preparation of a cyclic dinucleotide which is useful as a STING agonist of the following formula (I), involving the use of compounds A and B.
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![NOVEL METHODS AND INTERMEDIATES FOR THE PREPARATION OF (4bS,5aR)-12-CYCLOHEXYL-N-(N,N-DIMETHYLSULFAMOYL)-3-METHOXY-5a-((1R,5S)-3-METHYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBONYL)-4b,5,5a,6-TETRAHYDROBENZO [3,4]CYCLOPROPA[5,6]AZEPINO[1,2-A]INDOLE-9-CARBOXAMIDE](/abs-image/US/2015/05/14/US20150133654A1/abs.jpg.150x150.jpg)
3.发明申请NOVEL METHODS AND INTERMEDIATES FOR THE PREPARATION OF (4bS,5aR)-12-CYCLOHEXYL-N-(N,N-DIMETHYLSULFAMOYL)-3-METHOXY-5a-((1R,5S)-3-METHYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBONYL)-4b,5,5a,6-TETRAHYDROBENZO [3,4]CYCLOPROPA[5,6]AZEPINO[1,2-A]INDOLE-9-CARBOXAMIDE 有权制备（4bS，5R）-12-环己基-N-（N，N-二甲基甲酰基）-3-甲氧基-5a-（（1R，5S）-3-甲基-3,8-二氮杂双环十六烷基的新方法和中间体 [3.2.1]月桂基-8-羰基）-4b，5,5a，6-四氢苯并[3,4]环丙基[5,6]亚氨基[1,2-A]吲哚-9-羧酰胺公开(公告)号：US20150133654A1
公开(公告)日：2015-05-14
申请号：US14414475
申请日：2013-07-16
发明人： Albert J. DelMonte , Kenneth J. Natalie, JR. , Kenneth J. Fraunhoffer , Christina Ann Risatti , Chao Hang , Zhinong Gao , Akin H. Davulcu , Wenhao Hu
IPC分类号： C07D519/00 , C07D487/04 , C07C69/734 , C07C62/10 , C07C211/45 , C07C69/757 , C07D209/08 , C07C233/05
CPC分类号： C07D519/00 , C07C62/10 , C07C69/734 , C07C69/757 , C07C211/45 , C07C233/05 , C07D209/08 , C07D487/04
摘要： The present invention provides methods and intermediates for the preparation of (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide (formula I), including pharmaceutically acceptable salts. The compound has activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
摘要翻译： 本发明提供了制备（1aR，12bS）-8-环己基-11-氟-N（（1-甲基环丙基）磺酰基）-1a - （（3-甲基-3,8-二氮杂双环[ 3.2.1]辛-8-基）羰基）-1,1a，2,12b-四氢环丙[d]吲哚并[2,1-a] [2]苯并氮杂-5-甲酰胺（式I），包括药学上可接受的盐 。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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