Invention Grant
- Patent Title: Haplotying of HLA loci with ultra-deep shotgun sequencing
- Patent Title (中): 用超深霰弹枪测序法整合HLA基因座
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Application No.: US14161515Application Date: 2014-01-22
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Publication No.: US09562269B2Publication Date: 2017-02-07
- Inventor: Chunlin Wang , Michael N. Mindrinos , Mark M. Davis , Ronald W. Davis , Sujatha Krishnakumar
- Applicant: The Board of Trustees of the Leland Stanford Junior University
- Applicant Address: US CA Stanford
- Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US CA Stanford
- Agency: Bozicevic, Field & Francis LLP
- Agent Pamela J. Sherwood
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; G06F19/22 ; G06F19/18
Abstract:
Methods are provided to determine the entire genomic region of a particular HLA locus including both intron and exons. The resultant consensus sequences provides linkage information between different exons, and produces the unique sequence from each of the two genes from the individual sample being typed. The sequence information in intron regions along with the exon sequences provides an accurate HLA haplotype.
Public/Granted literature
- US20140206547A1 HAPLOTYING OF HLA LOCI WITH ULTRA-DEEP SHOTGUN SEQUENCING Public/Granted day:2014-07-24
Information query
