Provided is an RPG disruption system (RDS) for protecting an enclosure against RPG's, the system including a casing fixed in close proximity to a wall of the enclosure facing an anticipated RPG threat. The casing includes an anvil accommodating a propelling mechanism for propelling the disrupting element, and an activating system for activating the propelling mechanism so as to propel the disrupting element towards an approaching RPG, to thereby neutralize it.