Invention Grant
- Patent Title: Super-resolution microscopy method and device
- Patent Title (中): 超分辨率显微镜方法和装置
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Application No.: US14411373Application Date: 2012-10-22
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Publication No.: US09568417B2Publication Date: 2017-02-14
- Inventor: Cuifang Kuang , Shuai Li , Xiang Hao , Zhaotai Gu , Xu Liu
- Applicant: ZHEJIANG UNIVERSITY
- Applicant Address: CN Hangzhou
- Assignee: ZHEJIANG UNIVERSITY
- Current Assignee: ZHEJIANG UNIVERSITY
- Current Assignee Address: CN Hangzhou
- Agent Jiwen Chen
- Priority: CN201210227898 20120629
- International Application: PCT/CN2012/083320 WO 20121022
- International Announcement: WO2014/000351 WO 20140103
- Main IPC: G01J4/00
- IPC: G01J4/00 ; G01N21/27 ; G02B21/00 ; G01N21/64 ; G01N21/25 ; G02B27/58

Abstract:
This invention discloses a super-resolution microscopy method and device, of which the method comprises the following steps: converting laser beam into linearly polarized light after collimation; linearly polarized light is deflected and phase modulated by a spatial light modulator; the deflected beam is focused, collimated and then converted into circularly polarized light for projection on the sample to collect signal light from various scanning points on the sample, and obtaining the first signal light intensity; switching over modulation function to project linearly polarized light modulated by the second phase modulation on the sample to collect signal light from various scanning points on the sample, and obtaining the second signal light intensity; calculating valid signal light intensity to obtain the super-resolution image. This device features in a simple structure and easy operation, which can obtain a super-resolution beyond diffraction limit at a lower luminous power; it is quick in image formation with the frame frequency over 15 frames when the number of scanning points in each image is 512×512.
Public/Granted literature
- US20150211986A1 SUPER-RESOLUTION MICROSCOPY METHOD AND DEVICE Public/Granted day:2015-07-30
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