发明授权
US09572909B2 Electrospun nerve guides for nerve regeneration designed to modulate nerve architecture
有权
用于神经再生的电极神经导管设计用于调节神经结构
- 专利标题： Electrospun nerve guides for nerve regeneration designed to modulate nerve architecture
- 专利标题（中）： 用于神经再生的电极神经导管设计用于调节神经结构
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申请号： US13394415申请日： 2010-09-14
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公开(公告)号： US09572909B2公开(公告)日： 2017-02-21
- 发明人: David Simpson , Gary Bowlin , Raymond Colello , Woon Chow , Balendu Shekhar Jha
- 申请人： David Simpson , Gary Bowlin , Raymond Colello , Woon Chow , Balendu Shekhar Jha
- 申请人地址： US VA Richmond
- 专利权人： Virginia Commonwealth University
- 当前专利权人： Virginia Commonwealth University
- 当前专利权人地址： US VA Richmond
- 代理机构： Whitham, Curtis & Cook, P.C.
- 国际申请： PCT/US2010/048744 WO 20100914
- 国际公布： WO2011/032139 WO 20110317
- 主分类号： A61L27/18
- IPC分类号： A61L27/18 ; A61F2/02 ; A61B17/11
摘要：
Nerve guides which are formed from three dimensional (3D) arrays of highly aligned electrospun fibers are provided. The electrospun fibers are oriented parallel to the long axis of the guide, and gaps and elongated spaces between the stacked fiber arrays provide channels for directed axonal growth. In some embodiments, the nerve guides also comprise high precision gradients of beneficial substances such as growth factors, which aid in nerve regeneration and growth along the guide.
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