公开(公告)号：US20120221025A1

公开(公告)日：2012-08-30

申请号：US13394415

申请日：2010-09-14

申请人： David Simpson ,  Gary Bowlin ,  Raymond Colello ,  Woon Chow ,  Balendu Shekhar Jha

发明人： David Simpson ,  Gary Bowlin ,  Raymond Colello ,  Woon Chow ,  Balendu Shekhar Jha

IPC分类号： A61F2/02 ,  B29C35/16

CPC分类号： A61L27/18 ,  A61B17/1128 ,  A61F2/02 ,  A61L2430/32 ,  C08L67/04

摘要： Nerve guides which are formed from three dimensional (3D) arrays of highly aligned electrospun fibers are provided. The electrospun fibers are oriented parallel to the long axis of the guide, and gaps and elongated spaces between the stacked fiber arrays provide channels for directed axonal growth. In some embodiments, the nerve guides also comprise high precision gradients of beneficial substances such as growth factors, which aid in nerve regeneration and growth along the guide.

摘要翻译： 提供由高度排列的电纺纤维的三维（3D）阵列形成的神经引导件。 电纺纤维被定向成平行于引导件的长轴线，并且叠置的光纤阵列之间的间隙和细长空间提供用于定向轴突生长的通道。 在一些实施例中，神经导向器还包括诸如生长因子的有益物质的高精度梯度，其有助于神经再生和沿着引导物的生长。

公开(公告)号：US09572909B2

公开(公告)日：2017-02-21

申请号：US13394415

申请日：2010-09-14

申请人： David Simpson ,  Gary Bowlin ,  Raymond Colello ,  Woon Chow ,  Balendu Shekhar Jha

发明人： David Simpson ,  Gary Bowlin ,  Raymond Colello ,  Woon Chow ,  Balendu Shekhar Jha

IPC分类号： A61L27/18 ,  A61F2/02 ,  A61B17/11

CPC分类号： A61L27/18 ,  A61B17/1128 ,  A61F2/02 ,  A61L2430/32 ,  C08L67/04

摘要： Nerve guides which are formed from three dimensional (3D) arrays of highly aligned electrospun fibers are provided. The electrospun fibers are oriented parallel to the long axis of the guide, and gaps and elongated spaces between the stacked fiber arrays provide channels for directed axonal growth. In some embodiments, the nerve guides also comprise high precision gradients of beneficial substances such as growth factors, which aid in nerve regeneration and growth along the guide.

摘要翻译： 提供由高度排列的电纺纤维的三维（3D）阵列形成的神经引导件。 电纺纤维被定向成平行于引导件的长轴线，并且叠置的光纤阵列之间的间隙和细长空间提供用于定向轴突生长的通道。 在一些实施例中，神经导向器还包括诸如生长因子的有益物质的高精度梯度，其有助于神经再生和沿着引导物的生长。