Invention Grant
US09573991B2 Human monoclonal antibodies derived from human B cells and having neutralizing activity against influenza A viruses
有权
来自人B细胞并具有针对甲型流感病毒的中和活性的人单克隆抗体
- Patent Title: Human monoclonal antibodies derived from human B cells and having neutralizing activity against influenza A viruses
- Patent Title (中): 来自人B细胞并具有针对甲型流感病毒的中和活性的人单克隆抗体
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Application No.: US13583529Application Date: 2011-03-07
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Publication No.: US09573991B2Publication Date: 2017-02-21
- Inventor: Shin Jae Chang , Jong Mook Kim , Kye Sook Yi , Hyun Joo Lee
- Applicant: Shin Jae Chang , Jong Mook Kim , Kye Sook Yi , Hyun Joo Lee
- Applicant Address: KR Incheon
- Assignee: CELLTRION, INC.
- Current Assignee: CELLTRION, INC.
- Current Assignee Address: KR Incheon
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Agent Kongsik Kim
- Priority: KR10-2010-0020587 20100308
- International Application: PCT/KR2011/001563 WO 20110307
- International Announcement: WO2011/111966 WO 20110915
- Main IPC: C07K16/10
- IPC: C07K16/10 ; A61K39/42 ; G01N33/569 ; A61K39/00
Abstract:
The present invention relates to human monoclonal antibodies derived from human B cells present in the blood of patients who had recovered from infection with influenza A viruses, wherein the monoclonal antibodies have neutralizing activity against influenza A viruses. The anti-influenza A virus monoclonal antibody of the present invention has binding and neutralizing activities against at least one influenza A virus selected from the group consisting of influenza A virus H1, H2 and H5 subtypes, and thus it is useful for the prevention and treatment of a disease caused by the influenza A virus and is also useful for diagnosis of influenza A virus infection.
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